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    Ogfrl1 opioid growth factor receptor-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 70155, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ogfrl1provided by MGI
    Official Full Name
    opioid growth factor receptor-like 1provided by MGI
    Primary source
    MGI:MGI:1917405
    See related
    Ensembl:ENSMUSG00000026158 AllianceGenome:MGI:1917405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2210417C17Rik
    Summary
    Predicted to enable opioid growth factor receptor activity. Predicted to be located in membrane. Is expressed in forebrain; ganglia; and genitourinary system. Orthologous to human OGFRL1 (opioid growth factor receptor like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 19.4), cortex adult (RPKM 16.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ogfrl1 in Genome Data Viewer
    Location:
    1 A5; 1 9.57 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (23405505..23422282, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (23366424..23383201, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53541 Neighboring gene microRNA 30c-2 Neighboring gene STARR-seq mESC enhancer starr_00429 Neighboring gene STARR-seq mESC enhancer starr_00430 Neighboring gene STARR-seq mESC enhancer starr_00431 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene Neighboring gene STARR-seq mESC enhancer starr_00432 Neighboring gene predicted gene, 19673 Neighboring gene STARR-seq mESC enhancer starr_00434 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gene expression analysis of the embryonic subplate. Oeschger FM, et al. Cereb Cortex, 2012 Jun. PMID 21862448, Free PMC Article
    2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables opioid growth factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    opioid growth factor receptor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081079.1 → NP_001074548.1  opioid growth factor receptor-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001074548.1

      Status: VALIDATED

      Source sequence(s)
      AC165368
      Consensus CDS
      CCDS35526.1
      UniProtKB/Swiss-Prot
      Q8VE52
      Related
      ENSMUSP00000027343.6, ENSMUST00000027343.6
      Conserved Domains (2) summary
      pfam05887
      Location:6 → 93
      Trypan_PARP; Procyclic acidic repetitive protein (PARP)
      pfam04664
      Location:114 → 319
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region

    2. NM_001379082.1 → NP_001366011.1  opioid growth factor receptor-like protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165368
      Conserved Domains (2) summary
      COG4223
      Location:322 → 433
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam04664
      Location:115 → 320
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region

    3. NM_001379083.1 → NP_001366012.1  opioid growth factor receptor-like protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC165368
      Conserved Domains (2) summary
      COG4223
      Location:250 → 361
      COG4223; Uncharacterized conserved protein [Function unknown]
      pfam04664
      Location:114 → 248
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      23405505..23422282 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE52.2 GenPept UniProtKB/Swiss-Prot:Q8VE52

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