Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abl2provided by MGI
Official Full Name: ABL proto-oncogene 2, non-receptor tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:87860
See related: Ensembl:ENSMUSG00000026596 AllianceGenome:MGI:87860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arg; Abll
Summary: Enables magnesium ion binding activity; manganese ion binding activity; and protein tyrosine kinase activity. Involved in several processes, including positive regulation of T cell migration; positive regulation of establishment of T cell polarity; and synapse maturation. Acts upstream of or within several processes, including T cell differentiation; nervous system development; and regulation of signal transduction. Located in several cellular components, including dendritic spine; lamellipodium; and phagocytic cup. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; diaphragm; hemolymphoid system gland; hindlimb long bone; and seminiferous cord. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 5.8), whole brain E14.5 (RPKM 3.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G3; 1 67.71 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (156386160..156477189)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (156558590..156649619)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.
Title: Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice.
Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Title: Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway inactivation.
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
Title: Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion.
Title: The NSs Protein Encoded by the Virulent Strain of Rift Valley Fever Virus Targets the Expression of Abl2 and the Actin Cytoskeleton of the Host, Affecting Cell Mobility, Cell Shape, and Cell-Cell Adhesion.
Abl2 uses its C-terminal half to bind microtubules (MTs) and directly regulate MT dynamics
Title: Regulation of MT dynamics via direct binding of an Abl family kinase.
we demonstrate that the non-synonymous single nucleotide polymorphism does not change Arg's binding affinity for F-actin but suggest a role for Abl kinases in CNS inflammation pathogenesis
Title: A Role for the Non-Receptor Tyrosine Kinase Abl2/Arg in Experimental Neuroinflammation.
Data suggest that Abl2 on chromosome 1 and Nlrp3 on chromosome 11 are key to spermatozoa function; here, genetic polymorphisms in Abl2 and Nlrp3 appear to regulate susceptibility of mouse spermatozoa to cryopreservation. (Abl2 = v-abl Abelson murine leukemia viral oncogene 2; Nlrp3 = NLR family pyrin domain containing protein-3)
Title: Identification of quantitative trait loci associated with the susceptibility of mouse spermatozoa to cryopreservation.
Study shows that Abelson tyrosine-protein kinase 2 (Abl2) has a key role in regulating myofiber length, as a loss of Abl2 leads to excessively long myofibers in the diaphragm, intercostal and levator auris muscles but not limb muscles.
Title: Abelson tyrosine-protein kinase 2 regulates myoblast proliferation and controls muscle fiber length.
Overexpression of Abl-related gene tyrosine kinase ABL2 in pro-B cell line Ba/F3 cells expressing an oncogenic mutant of FLT3 (FLT3-ITD) resulted in partial inhibition of FLT3-ITD-dependent cell proliferation.
Title: ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling.
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
Title: The Src kinases Hck, Fgr and Lyn activate Arg to facilitate IgG-mediated phagocytosis and Leishmania infection.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (2) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234240

AA925877 (e-PCR)
- UniSTS:248586

D1Mit425 (e-PCR), detects polymorphism
- UniSTS:128791

RH124499 (e-PCR)
- UniSTS:161321

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

BB283609 (e-PCR)
- UniSTS:207235

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotyrosine residue binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Bergmann glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within DN4 thymocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within actin filament organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within alpha-beta T cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within auditory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebellum morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dendritic spine maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exploration behavior	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of endothelial cell apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural tube closure	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuroepithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuromuscular process controlling balance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of T cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type II interferon production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substrate-dependent cell migration, cell extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	TAS Traceable Author Statement more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase ABL2

Names: Abelson tyrosine-protein kinase 2; Abelson-related gene protein; abelson murine leukemia viral oncogene homolog 2; tyrosine kinase ARG; tyrosine-protein kinase ARG; v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene); v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)

NP_001129576.1

EC 2.7.10.2

NP_033725.2

EC 2.7.10.2

XP_006496676.1

EC 2.7.10.2

XP_006496677.1

EC 2.7.10.2

XP_006496678.1

EC 2.7.10.2

XP_006496679.1

EC 2.7.10.2

XP_006496680.1

EC 2.7.10.2

XP_006496683.1

EC 2.7.10.2

XP_006496684.1

EC 2.7.10.2

XP_006496685.1

EC 2.7.10.2

XP_011237039.1

EC 2.7.10.2

XP_011237040.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001136104.1 → NP_001129576.1 tyrosine-protein kinase ABL2 isoform a

See identical proteins and their annotated locations for NP_001129576.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an in-frame segment in the 3' coding region, as compared to variant 2. The resulting isoform (a, also known as 1BLCTS) lacks an internal segment in the C-termius, as compared to isoform b.

Source sequence(s)

AC145078, BC137771, CJ171655

Consensus CDS

CCDS48404.1

UniProtKB/TrEMBL

B2RQ57, B7ZMZ2

Related

ENSMUSP00000126181.3, ENSMUST00000166172.9

Conserved Domains (5) summary

smart00808
Location:959 → 1078

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:288 → 539

STYKc; Protein kinase; unclassified specificity

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
NM_009595.3 → NP_033725.2 tyrosine-protein kinase ABL2 isoform b

See identical proteins and their annotated locations for NP_033725.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) encodes the longer isoform (b, also known as 1BLCTL).

Source sequence(s)

AC145078, BC137771, CJ171655

Consensus CDS

CCDS15393.1

UniProtKB/Swiss-Prot

Q4JIM5

UniProtKB/TrEMBL

F8VQH0

Related

ENSMUSP00000027888.7, ENSMUST00000027888.13

Conserved Domains (5) summary

smart00808
Location:1063 → 1182

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

smart00221
Location:288 → 539

STYKc; Protein kinase; unclassified specificity

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

156386160..156477189

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011238737.3 → XP_011237039.1 tyrosine-protein kinase ABL2 isoform X1

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1062 → 1181

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_011238738.3 → XP_011237040.1 tyrosine-protein kinase ABL2 isoform X7

UniProtKB/TrEMBL

B7ZMZ2

Conserved Domains (4) summary

smart00808
Location:958 → 1077

FABD; F-actin binding domain (FABD)

cd09935
Location:169 → 262

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:111 → 164

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:281 → 543

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496615.4 → XP_006496678.1 tyrosine-protein kinase ABL2 isoform X4

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1042 → 1161

FABD; F-actin binding domain (FABD)

cd09935
Location:148 → 241

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:90 → 143

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:260 → 522

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496616.4 → XP_006496679.1 tyrosine-protein kinase ABL2 isoform X5

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1041 → 1160

FABD; F-actin binding domain (FABD)

cd09935
Location:148 → 241

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:90 → 143

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:260 → 522

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496621.4 → XP_006496684.1 tyrosine-protein kinase ABL2 isoform X9

UniProtKB/TrEMBL

B7ZMZ2

Conserved Domains (4) summary

smart00808
Location:937 → 1056

FABD; F-actin binding domain (FABD)

cd09935
Location:148 → 241

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:90 → 143

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:260 → 522

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496613.5 → XP_006496676.1 tyrosine-protein kinase ABL2 isoform X2

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1048 → 1167

FABD; F-actin binding domain (FABD)

cd09935
Location:154 → 247

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:96 → 149

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:266 → 528

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496614.5 → XP_006496677.1 tyrosine-protein kinase ABL2 isoform X3

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1047 → 1166

FABD; F-actin binding domain (FABD)

cd09935
Location:154 → 247

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:96 → 149

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:266 → 528

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496617.5 → XP_006496680.1 tyrosine-protein kinase ABL2 isoform X6

UniProtKB/Swiss-Prot

Q4JIM5

Conserved Domains (4) summary

smart00808
Location:1027 → 1146

FABD; F-actin binding domain (FABD)

cd09935
Location:133 → 226

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:75 → 128

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:245 → 507

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496620.5 → XP_006496683.1 tyrosine-protein kinase ABL2 isoform X8

UniProtKB/TrEMBL

B7ZMZ2

Conserved Domains (4) summary

smart00808
Location:943 → 1062

FABD; F-actin binding domain (FABD)

cd09935
Location:154 → 247

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:96 → 149

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:266 → 528

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
XM_006496622.5 → XP_006496685.1 tyrosine-protein kinase ABL2 isoform X10

UniProtKB/TrEMBL

B7ZMZ2

Conserved Domains (4) summary

smart00808
Location:922 → 1041

FABD; F-actin binding domain (FABD)

cd09935
Location:133 → 226

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

cd11850
Location:75 → 128

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

cd05052
Location:245 → 507

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase