Cma2 chymase 2, mast cell [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cma2provided by MGI
Official Full Name: chymase 2, mast cellprovided by MGI
Primary source: MGI:MGI:88426
See related: Ensembl:ENSMUSG00000068289 AllianceGenome:MGI:88426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mcp10
Summary: Predicted to enable heparin binding activity; peptide binding activity; and serine-type endopeptidase activity. Predicted to be involved in protein catabolic process and protein maturation. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56188437..56211488)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55950980..55989785)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mast cell chymase inhibits the apolipoprotein-mediated removal of macrophage cholesterol in foam cells of apoA-I knockout mice.
Title: Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mast cell protease 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024714.3 → NP_001019885.1 mast cell protease 10 isoform 1 precursor

See identical proteins and their annotated locations for NP_001019885.1

Status: VALIDATED

Source sequence(s)

AC163646

Consensus CDS

CCDS27136.1

UniProtKB/Swiss-Prot

Q00356

UniProtKB/TrEMBL

Q91VB1, Q9EPR0

Related

ENSMUSP00000086984.3, ENSMUST00000089555.3

Conserved Domains (2) summary

smart00020
Location:20 → 239

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:21 → 242

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001361637.1 → NP_001348566.1 mast cell protease 10 isoform 2

Status: VALIDATED

Source sequence(s)

AC163646

Consensus CDS

CCDS88672.1

UniProtKB/TrEMBL

A0A2I3BR33, Q8VDE7

Related

ENSMUSP00000154424.2, ENSMUST00000228263.2

Conserved Domains (1) summary

cd00190
Location:13 → 186

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...