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    Csn1s2b casein alpha s2-like B [ Mus musculus (house mouse) ]

    Gene ID: 12992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csn1s2bprovided by MGI
    Official Full Name
    casein alpha s2-like Bprovided by MGI
    Primary source
    MGI:MGI:105312
    See related
    Ensembl:ENSMUSG00000061388 AllianceGenome:MGI:105312
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Csnd; Csne
    Summary
    This gene is a member of the alpha-s2-like casein gene family, and this gene product is a calcium-sensitive casein. Members of this gene family are organized as a gene cluster that is conserved in its order, but with greater conservation amongst orthologs than paralogs. The protein encoded by this gene interacts with other casein proteins to form a micelle structure, and is a major source of protein in milk. This structure is important for the transport of calcium, phosphate, and protein. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Aug 2014]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Csn1s2b in Genome Data Viewer
    Location:
    5 E1; 5 43.56 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (87955980..87972280)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (87808121..87824421)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24314 Neighboring gene STARR-seq mESC enhancer starr_13563 Neighboring gene casein alpha s2-like A Neighboring gene STARR-seq mESC enhancer starr_13564 Neighboring gene proline rich 27 Neighboring gene DAZ interacting protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland. Lee HK, et al. Nat Commun, 2021 Apr 14. PMID 33854063, Free PMC Article
    2. Nucleotide sequence of cloned cDNA coding for mouse epsilon casein. Hennighausen LG, et al. Eur J Biochem, 1982 Sep 1. PMID 6897225
    3. Characterization and cloning of the mRNAs specific for the lactating mouse mammary gland. Hennighausen LG, et al. Eur J Biochem, 1982 Jun 15. PMID 6896688
    4. Restriction map of two yeast artificial chromosomes spanning the murine casein locus. Tomlinson AM, et al. Mamm Genome, 1996 Jul. PMID 8672136
    5. Physical mapping of the murine casein locus reveals the gene order as alpha-beta-gamma-epsilon-kappa. George S, et al. DNA Cell Biol, 1997 Apr. PMID 9150435

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland.
      Title: Redundant and non-redundant cytokine-activated enhancers control Csn1s2b expression in the lactating mouse mammary gland.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zymogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    alpha-S2-casein-like B
    Names
    casein delta
    epsilon-casein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301334.1 → NP_001288263.1  alpha-S2-casein-like B isoform 2 precursor

      See identical proteins and their annotated locations for NP_001288263.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK085744, AK164763, AK164767
      Consensus CDS
      CCDS80319.1
      UniProtKB/TrEMBL
      Q3TP31
      Related
      ENSMUSP00000108904.2, ENSMUST00000113279.8
      Conserved Domains (1) summary
      pfam00363
      Location:60 → 120
      Casein; Casein

    2. NM_001301335.1 → NP_001288264.1  alpha-S2-casein-like B isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.
      Source sequence(s)
      AK085744, AK164767
      Consensus CDS
      CCDS80320.1
      UniProtKB/TrEMBL
      A0A0G2JDP4
      Related
      ENSMUSP00000142449.2, ENSMUST00000197301.2
      Conserved Domains (1) summary
      pfam00363
      Location:49 → 121
      Casein; Casein

    3. NM_009973.3 → NP_034103.2  alpha-S2-casein-like B isoform 1 precursor

      See identical proteins and their annotated locations for NP_034103.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK085744, AK164767
      Consensus CDS
      CCDS39133.1
      UniProtKB/Swiss-Prot
      P02664, Q3TP28, Q3TP29, Q542L5
      Related
      ENSMUSP00000072352.6, ENSMUST00000072539.12
      Conserved Domains (1) summary
      pfam00363
      Location:60 → 132
      Casein; Casein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      87955980..87972280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02664.1 GenPept UniProtKB/Swiss-Prot:P02664

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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