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    Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta [ Mus musculus (house mouse) ]

    Gene ID: 108083, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pip4k2bprovided by MGI
    Official Full Name
    phosphatidylinositol-5-phosphate 4-kinase, type II, betaprovided by MGI
    Primary source
    MGI:MGI:1934234
    See related
    Ensembl:ENSMUSG00000018547 AllianceGenome:MGI:1934234
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c11; Pip5k2b; PI5P4Kbeta
    Summary
    Predicted to enable phosphatidylinositol kinase activity; protein homodimerization activity; and purine ribonucleoside triphosphate binding activity. Involved in autophagosome-lysosome fusion and regulation of autophagy. Acts upstream of or within phosphatidylinositol metabolic process. Predicted to be located in autophagosome and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in head bone; nervous system; and sensory organ. Orthologous to human PIP4K2B (phosphatidylinositol-5-phosphate 4-kinase type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 28.7), whole brain E14.5 (RPKM 24.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pip4k2b in Genome Data Viewer
    Location:
    11 D; 11 61.07 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97605983..97635530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97715157..97744704, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7051 Neighboring gene STARR-positive B cell enhancer ABC_E1430 Neighboring gene nuclear encoded tRNA asparagine 8 (anticodon GTT) Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:97606458-97606567 Neighboring gene microRNA 8102 Neighboring gene CWC25 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E2368

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Lamia KA, et al. Mol Cell Biol, 2004 Jun. PMID 15143198, Free PMC Article
    2. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Lundquist MR, et al. Mol Cell, 2018 May 3. PMID 29727621, Free PMC Article
    3. PIP4K and the role of nuclear phosphoinositides in tumour suppression. Fiume R, et al. Biochim Biophys Acta, 2015 Jun. PMID 25728392
    4. A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase. Castellino AM, et al. J Biol Chem, 1997 Feb 28. PMID 9038203
    5. PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay. Ravi A, et al. Dev Cell, 2021 Jun 7. PMID 33984270, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
      Title: Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain.
    2. Suppression of PIP4K expression selectively prevents tumor cell growth in vitro and prevents tumor development in mice that have lost the tumor suppressor p53. (Review)
      Title: PIP4K and the role of nuclear phosphoinositides in tumour suppression.
    3. located within a 185-kb contig surrounding a transgene on chromosome 11
      Title: Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-5-phosphate 4-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in autophagosome-lysosome fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of autophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in autophagosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in autophagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 5-phosphate 4-kinase type-2 beta
    Names
    1-phosphatidylinositol 5-phosphate 4-kinase 2-beta
    PI(5)P 4-kinase type II beta
    PIP4KII-beta
    diphosphoinositide kinase 2-beta
    phosphatidylinositol-4-phosphate 5-kinase, type II, beta
    NP_473392.1
    XP_030101326.1
    XP_036012113.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054051.1 → NP_473392.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta

      See identical proteins and their annotated locations for NP_473392.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047282
      Consensus CDS
      CCDS25329.1
      UniProtKB/Swiss-Prot
      Q80XI4, Q8VHB2
      UniProtKB/TrEMBL
      Q3UJ95
      Related
      ENSMUSP00000018691.9, ENSMUST00000018691.9
      Conserved Domains (1) summary
      cd17310
      Location:30 → 413
      PIPKc_PIP5K2B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP5K2B) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97605983..97635530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156220.1 → XP_036012113.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

      Conserved Domains (1) summary
      cl28923
      Location:1 → 349
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family

    2. XM_030245466.2 → XP_030101326.1  phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1

      Conserved Domains (1) summary
      cl28923
      Location:1 → 349
      PIPKc; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80XI4.1 GenPept UniProtKB/Swiss-Prot:Q80XI4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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