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    Bpifa3 BPI fold containing family A, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 73388, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Bpifa3provided by MGI
    Official Full Name
    BPI fold containing family A, member 3provided by MGI
    Primary source
    MGI:MGI:1920638
    See related
    Ensembl:ENSMUSG00000027482 AllianceGenome:MGI:1920638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Splunc3; 1700058C13Rik
    Summary
    Predicted to enable lipid binding activity. Predicted to be located in extracellular region. Orthologous to human BPIFA3 (BPI fold containing family A member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 69.4) See more
    Orthologs
    human all
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    Genomic context

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    See Bpifa3 in Genome Data Viewer
    Location:
    2 H1; 2 76.15 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (153972222..153980279)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (154130302..154138359)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BPI fold containing family A, member 2 Neighboring gene Friend virus susceptibility protein 1-like Neighboring gene STARR-seq mESC enhancer starr_06110 Neighboring gene BPI fold containing family A, member 1 Neighboring gene BPI fold containing family A, member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    2. Phylogenetic and evolutionary analysis of the PLUNC gene family. Bingle CD, et al. Protein Sci, 2004 Feb. PMID 14739326, Free PMC Article
    3. Systematic nomenclature for the PLUNC/PSP/BSP30/SMGB proteins as a subfamily of the BPI fold-containing superfamily. Bingle CD, et al. Biochem Soc Trans, 2011 Aug. PMID 21787333, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2)  1 citation
    • Targeted (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    BPI fold-containing family A member 3
    Names
    Novel LBP / BPI / CETP family, N-terminal domain containing protein
    short palate, lung and nasal epithelium carcinoma-associated protein 3 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291079.1 → NP_001278008.1  BPI fold-containing family A member 3 isoform b precursor

      See identical proteins and their annotated locations for NP_001278008.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in its 3' terminal exon, which results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AK006829, AL732466
      Consensus CDS
      CCDS71163.1
      UniProtKB/Swiss-Prot
      Q9D9J8
      Related
      ENSMUSP00000105368.2, ENSMUST00000109746.8
      Conserved Domains (1) summary
      pfam01273
      Location:40 → 219
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    2. NM_028528.3 → NP_082804.1  BPI fold-containing family A member 3 isoform a precursor

      See identical proteins and their annotated locations for NP_082804.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AK006829, AL732466
      Consensus CDS
      CCDS16924.1
      UniProtKB/TrEMBL
      Q80X83
      Related
      ENSMUSP00000028984.7, ENSMUST00000028984.13
      Conserved Domains (1) summary
      pfam01273
      Location:40 → 219
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      153972222..153980279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500259.2 → XP_006500322.1  BPI fold-containing family A member 3 isoform X1

      Conserved Domains (1) summary
      pfam01273
      Location:14 → 190
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    2. XM_030252118.1 → XP_030107978.1  BPI fold-containing family A member 3 isoform X2

      Conserved Domains (1) summary
      pfam01273
      Location:14 → 190
      LBP_BPI_CETP; LBP / BPI / CETP family, N-terminal domain

    RNA

    1. XR_003953724.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9J8.1 GenPept UniProtKB/Swiss-Prot:Q9D9J8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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