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    SBH2 Arf family guanine nucleotide exchange factor SBH2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SBH2
    Official Full Name
    Arf family guanine nucleotide exchange factor SBH2
    Primary source
    SGD:S000002127
    Locus tag
    YER019C-A
    See related
    AllianceGenome:SGD:S000002127; FungiDB:YER019C-A; VEuPathDB:YER019C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEB2
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in nuclear inner membrane. Part of Ssh1 translocon complex. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SBH2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (194273..194539, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene kinetochore-associated Ndc80 complex subunit SPC25 Neighboring gene inositol phosphosphingolipid phospholipase Neighboring gene guanine nucleotide-binding protein subunit alpha Neighboring gene proteasome regulatory particle lid subunit RPN3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The beta-subunit of the protein-conducting channel of the endoplasmic reticulum functions as the guanine nucleotide exchange factor for the beta-subunit of the signal recognition particle receptor. Helmers J, et al. J Biol Chem, 2003 Jun 27. PMID 12750387
    2. Mechanism of polypeptide translocation into the endoplasmic reticulum. Corsi AK, et al. J Biol Chem, 1996 Nov 29. PMID 8939984
    3. Kluyveromyces lactis SSO1 and SEB1 genes are functional in Saccharomyces cerevisiae and enhance production of secreted proteins when overexpressed. Toikkanen JH, et al. Yeast, 2004 Sep. PMID 15449305
    4. Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Becker T, et al. Science, 2009 Dec 4. PMID 19933108, Free PMC Article
    5. Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit. Toikkanen J, et al. Yeast, 1996 Apr. PMID 8740416

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Ssh1 translocon complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Arf family guanine nucleotide exchange factor SBH2
    NP_010936.1
    • Ssh1p-Sss1p-Sbh2p complex component; involved in protein translocation into the endoplasmic reticulum; SBH2 has a paralog, SBH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      194273..194539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180031.1 → NP_010936.1  TPA: Arf family guanine nucleotide exchange factor SBH2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010936.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLR8, P52871, Q53X22
      UniProtKB/TrEMBL
      A6ZQW8, B3LS32, C7GKJ8, C8Z720, G2WCQ2, N1P3Y4
      Conserved Domains (1) summary
      pfam03911
      Location:45 → 81
      Sec61_beta; Sec61beta family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52871.1

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