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    TREML1 triggering receptor expressed on myeloid cells like 1 [ Homo sapiens (human) ]

    Gene ID: 340205, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TREML1provided by HGNC
    Official Full Name
    triggering receptor expressed on myeloid cells like 1provided by HGNC
    Primary source
    HGNC:HGNC:20434
    See related
    Ensembl:ENSG00000161911 MIM:609714; AllianceGenome:HGNC:20434
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
    Summary
    This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
    Expression
    Biased expression in bone marrow (RPKM 1.9), lymph node (RPKM 1.7) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TREML1 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41149260..41155403, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (40977812..40983997, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41116998..41122087, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17172 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17173 Neighboring gene O-acyl-ADP-ribose deacylase 1 Neighboring gene nuclear transcription factor Y subunit alpha Neighboring gene MPRA-validated peak5800 silencer Neighboring gene ADCY10 pseudogene 1 Neighboring gene triggering receptor expressed on myeloid cells 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17174 Neighboring gene uncharacterized LOC107986595

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia. He L, et al. Platelets, 2022 Nov 17. PMID 35348422
    2. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. Nurden AT, et al. Thromb Haemost, 2008 Jul. PMID 18612537, Free PMC Article
    3. Soluble TLT-1 modulates platelet-endothelial cell interactions and actin polymerization. Morales J, et al. Blood Coagul Fibrinolysis, 2010 Apr. PMID 20093931, Free PMC Article
    4. Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1. Giomarelli B, et al. Thromb Haemost, 2007 Jun. PMID 17549298
    5. Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease. Shu CC, et al. Int J Tuberc Lung Dis, 2011 Oct. PMID 22283904

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
      Title: Decreased level of TREM like Transcript 1 (TLT-1) is associated with prematurity and promotes the in-utero inflammatory response to maternal lipopolysaccharide (LPS) exposure.
    2. Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia.
      Title: Triggering receptor expressed on myeloid cells (TREM) like transcript-1 (TLT-1) reveals platelet activation in preeclampsia.
    3. TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis.
      Title: TLT-1 Promotes Platelet-Monocyte Aggregate Formation to Induce IL-10-Producing B Cells in Tuberculosis.
    4. Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.
      Title: Low-soluble TREM-like transcript-1 levels early after severe burn reflect increased coagulation disorders and predict 30-day mortality.
    5. Defining the TLT-1 interactome from resting and activated human platelets.
      Title: Defining the TLT-1 interactome from resting and activated human platelets.
    6. P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.
      Title: P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study.
    7. binding with macrophage membrane receptor, FcR1, initiates inflammatory signals in macrophages
      Title: Elevated level of circulatory sTLT1 induces inflammation through SYK/MEK/ERK signalling in coronary artery disease.
    8. we show that gene expression profiling of RUNX1 knock-down or mutated MK provides a suitable approach to identify novel RUNX1 targets, among which downregulation of TREML1 and ITGA2 clearly contribute to the platelet phenotype of familial platelet disorder with predisposition to AML.
      Title: Downregulation of TREM-like transcript-1 and collagen receptor α2 subunit, two novel RUNX1-targets, contributes to platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia.
    9. TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
      Title: TREM-like transcript 1: a more sensitive marker of platelet activation than P-selectin in humans and mice.
    10. Study characterized the expression of TREM genes in cerebellum and temporal cortex and determined TREML1 and TREM2 to be the only reliably expressed TREM genes in these brain regions; identified rs9357347 as a putative regulatory variant that is associated with protection from Alzheimer's disease and with increased TREML1 and TREM2 brain levels.
      Title: A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of triggering receptor expressed on myeloid cells-like 1 (TREML1) expression as compared to untreated control PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119173

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in platelet activation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in platelet alpha granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in platelet alpha granule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    trem-like transcript 1 protein
    Names
    triggering receptor expressed on myeloid cells-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271807.1 → NP_001258736.1  trem-like transcript 1 protein isoform b precursor

      See identical proteins and their annotated locations for NP_001258736.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AL133404, AY358357, BQ023322, DW009745
      Consensus CDS
      CCDS64421.1
      UniProtKB/Swiss-Prot
      Q86YW5
      Related
      ENSP00000362219.4, ENST00000373127.8
      Conserved Domains (1) summary
      cl11960
      Location:25 → 113
      Ig; Immunoglobulin domain

    2. NM_001271808.1 → NP_001258737.1  trem-like transcript 1 protein isoform c

      See identical proteins and their annotated locations for NP_001258737.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (c) is shorter compared to isoform a.
      Source sequence(s)
      AL133404, AY358357, BC100946, BQ023322, DW009745
      Consensus CDS
      CCDS64420.1
      UniProtKB/Swiss-Prot
      Q86YW5
      Related
      ENSP00000400405.1, ENST00000437044.2

    3. NM_178174.4 → NP_835468.1  trem-like transcript 1 protein isoform a precursor

      See identical proteins and their annotated locations for NP_835468.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL133404
      Consensus CDS
      CCDS4851.1
      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2
      Related
      ENSP00000402855.2, ENST00000426005.7
      Conserved Domains (1) summary
      cl11960
      Location:25 → 113
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      41149260..41155403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010825.2 → XP_016866314.1  trem-like transcript 1 protein isoform X3

    2. XM_017010822.2 → XP_016866311.1  trem-like transcript 1 protein isoform X1

    3. XM_017010823.2 → XP_016866312.1  trem-like transcript 1 protein isoform X2

      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2
      Conserved Domains (1) summary
      cl11960
      Location:25 → 113
      Ig; Immunoglobulin domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      40977812..40983997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054355322.1 → XP_054211297.1  trem-like transcript 1 protein isoform X3

    2. XM_054355320.1 → XP_054211295.1  trem-like transcript 1 protein isoform X1

    3. XM_054355321.1 → XP_054211296.1  trem-like transcript 1 protein isoform X2

      UniProtKB/Swiss-Prot
      Q496B3, Q86YW5, Q8IWY1, Q8IWY2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86YW5.2 GenPept UniProtKB/Swiss-Prot:Q86YW5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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