RPL34 ribosomal protein L34 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPL34provided by HGNC
Official Full Name: ribosomal protein L34provided by HGNC
Primary source: HGNC:HGNC:10340
See related: Ensembl:ENSG00000109475 MIM:616862; AllianceGenome:HGNC:10340
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: L34; eL34
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L34E family of ribosomal proteins. It is located in the cytoplasm. This gene originally was thought to be located at 17q21, but it has been mapped to 4q. Overexpression of this gene has been observed in some cancer cells. Alternative splicing results in multiple transcript variants, all encoding the same isoform. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Feb 2016]
Expression: Ubiquitous expression in ovary (RPKM 324.7), bone marrow (RPKM 227.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q25

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (108620576..108630484)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (111923483..111933392)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (109541732..109551640)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
Title: RPL34-AS1-induced RPL34 inhibits cervical cancer cell tumorigenesis via the MDM2-P53 pathway.
Findings indicated that knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
Title: Knockdown of RPL34 inhibits the proliferation and migration of glioma cells through the inactivation of JAK/STAT3 signaling pathway.
The present study combines an individual-based phenotypic profiling with a transdiagnostic approach and shows that several ribosomal genes including RPL34 is involved in stress vulnerability across nonclinical and clinical conditions.
Title: Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression.
The RPL34 gene was highly expressed in OSCC, while silencing RPL34 could block cell proliferation and metastasis, but promote cell apoptosis, suggesting the RPL34 gene to be a new promising clinical target for OSCC therapy.
Title: Influence of the RPL34 gene on the growth and metastasis of oral squamous cell carcinoma cells.
RPL34 plays an important role in the proliferation of osteosarcoma cells.
Title: Highly expressed ribosomal protein L34 indicates poor prognosis in osteosarcoma and its knockdown suppresses osteosarcoma proliferation probably through translational control.
RPL34 functions as an oncogene that modulates the proliferation and metastasis of esophageal cancer cells in part through the inactivation of the PI3K/Akt signaling pathway
Title: Silencing of Ribosomal Protein L34 (RPL34) Inhibits the Proliferation and Invasion of Esophageal Cancer Cells.
this study shows that ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells
Title: Ribosomal protein L34 promotes the proliferation, invasion and metastasis of pancreatic cancer cells.
RPL34 plays a critical role in cell proliferation, cell cycle distribution and apoptosis of human malignant gastric cells.
Title: RNAi-mediated RPL34 knockdown suppresses the growth of human gastric cancer cells.
over-expressed RPL34 may promote malignant proliferation of NSCLC cells, thus playing an important role in development and progress of NSCLC
Title: Over-expressed RPL34 promotes malignant proliferation of non-small cell lung cancer cells.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag interacts with RPL34 as demonstrated by proximity dependent biotinylation proteomics	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-59280 (e-PCR)
- UniSTS:22093

SHGC-67267 (e-PCR)
- UniSTS:79277

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	TAS Traceable Author Statement more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	HDA more info	PubMed
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in extracellular exosome	HDA more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: large ribosomal subunit protein eL34

Names: 60S ribosomal protein L34; leukemia-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000995.5 → NP_000986.2 large ribosomal subunit protein eL34

See identical proteins and their annotated locations for NP_000986.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1-6 all encode the same protein.

Source sequence(s)

BC106009, BM971961

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e
NM_001319232.2 → NP_001306161.1 large ribosomal subunit protein eL34

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.

Source sequence(s)

AA128015, AA128058, AC084209, CD175155, DA779124

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Related

ENSP00000423316.1, ENST00000506397.5

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e
NM_001319234.1 → NP_001306163.1 large ribosomal subunit protein eL34

Status: REVIEWED

Source sequence(s)

CB132938, DA779124

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e
NM_001319235.2 → NP_001306164.1 large ribosomal subunit protein eL34

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.

Source sequence(s)

AC084209, BE394007, CD175155, DA779124

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Related

ENSP00000378160.1, ENST00000394665.5

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e
NM_001319236.2 → NP_001306165.1 large ribosomal subunit protein eL34

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in its 5' and 3' UTRs compared to variant 2. Variants 1-6 all encode the same protein.

Source sequence(s)

BC106009, DA779124

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Related

ENSP00000378162.3, ENST00000394667.8

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e
NM_033625.4 → NP_296374.1 large ribosomal subunit protein eL34

See identical proteins and their annotated locations for NP_296374.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript. Variants 1-6 all encode the same protein.

Source sequence(s)

AC084209, BC001773, BM971961, CD175155

Consensus CDS

CCDS3680.1

UniProtKB/Swiss-Prot

P49207, Q6FG66, Q9BUZ2

Related

ENSP00000378163.2, ENST00000394668.3

Conserved Domains (1) summary

pfam01199
Location:1 → 96

Ribosomal_L34e; Ribosomal protein L34e