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    TUBGCP5 tubulin gamma complex component 5 [ Homo sapiens (human) ]

    Gene ID: 114791, updated on 10-Dec-2024

    Summary

    Official Symbol
    TUBGCP5provided by HGNC
    Official Full Name
    tubulin gamma complex component 5provided by HGNC
    Primary source
    HGNC:HGNC:18600
    See related
    Ensembl:ENSG00000275835 MIM:608147; AllianceGenome:HGNC:18600
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCP5
    Summary
    Enables microtubule binding activity. Involved in microtubule nucleation. Located in centrosome and cytosol. Part of gamma-tubulin ring complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 3.5) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See TUBGCP5 in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22983025..23039569, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20654893..20711463, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22833499..22890043)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr15:23086519-23086752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23080143-23080643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9155 Neighboring gene NIPA magnesium transporter 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23045427-23046179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9158 Neighboring gene NIPA magnesium transporter 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22999149-22999824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:22990202-22991401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22981163-22981662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22980661-22981162 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22925256-22925940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22905531-22906030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22896003-22896502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22895501-22896002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22893404-22894371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22892435-22893403 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22859095-22860005 Neighboring gene NANOG hESC enhancer GRCh37_chr15:22803142-22803643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22798435-22798945 Neighboring gene engulfment and cell motility 2 pseudogene 1 Neighboring gene WAS/WASL-interacting protein family member 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1899

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables gamma-tubulin binding  
    enables microtubule binding PubMed 
    contributes_to microtubule minus-end binding  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization  
    involved_in meiotic cell cycle  
    involved_in microtubule nucleation  
    involved_in microtubule nucleation PubMed 
    involved_in mitotic cell cycle  
    involved_in spindle assembly  
    Component Evidence Code Pubs
    located_in centrosome PubMed 
    located_in cytosol  
    located_in cytosol  
    part_of gamma-tubulin complex  
    part_of gamma-tubulin ring complex PubMed 
    located_in microtubule  
    located_in spindle pole  

    General protein information

    Preferred Names
    gamma-tubulin complex component 5
    Names
    gamma-tubulin complex component GCP5
    tubulin gamma complex associated protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102610.2 → NP_001096080.1  gamma-tubulin complex component 5 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site at its 3' terminal exon, compared to variant 1, and encodes isoform b. Isoforms a and b are identical in length but differ in their C-termini.
      Source sequence(s)
      AB067486, AC116166, AK056416
      Consensus CDS
      CCDS73697.1
      UniProtKB/TrEMBL
      A0A0G2JQX1
      Related
      ENSP00000481853.1, ENST00000620435.4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family
    2. NM_001354372.2 → NP_001341301.1  gamma-tubulin complex component 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family
    3. NM_001354373.2 → NP_001341302.1  gamma-tubulin complex component 5 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Related
      ENSP00000484566.1, ENST00000614508.4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family
    4. NM_001354374.2 → NP_001341303.1  gamma-tubulin complex component 5 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 928
      Spc97_Spc98; Spc97 / Spc98 family
    5. NM_001354375.2 → NP_001341304.1  gamma-tubulin complex component 5 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family
    6. NM_001354376.2 → NP_001341305.1  gamma-tubulin complex component 5 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166
      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:273 → 942
      Spc97_Spc98; Spc97 / Spc98 family
    7. NM_001354377.2 → NP_001341306.1  gamma-tubulin complex component 5 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice sites compared to variant 1, and encodes isoform h. Isoforms h and i are identical in length but differ in their C-termini.
      Source sequence(s)
      AC116166
      UniProtKB/TrEMBL
      A0A0G2JPW5, A8K1E4
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family
    8. NM_001354378.2 → NP_001341307.1  gamma-tubulin complex component 5 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) uses an alternate splice sites compared to variant 1, and encodes isoform i. Isoforms h and i are identical in length but differ in their C-termini.
      Source sequence(s)
      AC116166
      UniProtKB/TrEMBL
      A0A0G2JQX1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family
    9. NM_052903.6 → NP_443135.3  gamma-tubulin complex component 5 isoform a

      See identical proteins and their annotated locations for NP_443135.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Isoforms a and b are identical in length but differ in their C-termini.
      Source sequence(s)
      AB067486, BC071560
      Consensus CDS
      CCDS73698.1
      UniProtKB/Swiss-Prot
      E9PB12, Q6IQ52, Q96PY8, Q96RT8
      UniProtKB/TrEMBL
      A0A0G2JPW5, A8K1E4
      Related
      ENSP00000480316.1, ENST00000615383.5
      Conserved Domains (2) summary
      pfam04130
      Location:716 → 1017
      Spc97_Spc98; Spc97 / Spc98 family
      pfam17681
      Location:271 → 577
      GCP_N_terminal; Gamma tubulin complex component N-terminal

    RNA

    1. NR_148875.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC090764, AC116166

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      22983025..23039569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432130.1 → XP_047288086.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    2. XM_017021895.2 → XP_016877384.1  gamma-tubulin complex component 5 isoform X4

      UniProtKB/TrEMBL
      A8K1E4
    3. XM_017021894.2 → XP_016877383.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    4. XM_017021896.2 → XP_016877385.1  gamma-tubulin complex component 5 isoform X6

    5. XM_017021901.2 → XP_016877390.1  gamma-tubulin complex component 5 isoform X7

    6. XM_011543870.3 → XP_011542172.1  gamma-tubulin complex component 5 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family
    7. XM_011543868.3 → XP_011542170.1  gamma-tubulin complex component 5 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Z1
      Conserved Domains (1) summary
      pfam04130
      Location:274 → 943
      Spc97_Spc98; Spc97 / Spc98 family
    8. XM_047432131.1 → XP_047288087.1  gamma-tubulin complex component 5 isoform X5

      UniProtKB/TrEMBL
      A8K1E4

    RNA

    1. XR_007064420.1 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      3877112..3933660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332577.1 → XP_054188552.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    2. XM_054332579.1 → XP_054188554.1  gamma-tubulin complex component 5 isoform X4

      UniProtKB/TrEMBL
      A8K1E4
    3. XM_054332578.1 → XP_054188553.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    4. XM_054332581.1 → XP_054188556.1  gamma-tubulin complex component 5 isoform X6

    5. XM_054332582.1 → XP_054188557.1  gamma-tubulin complex component 5 isoform X7

    6. XM_054332576.1 → XP_054188551.1  gamma-tubulin complex component 5 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Z1
    7. XM_054332575.1 → XP_054188550.1  gamma-tubulin complex component 5 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Z1
    8. XM_054332580.1 → XP_054188555.1  gamma-tubulin complex component 5 isoform X5

      UniProtKB/TrEMBL
      A8K1E4

    RNA

    1. XR_008485783.1 RNA Sequence

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187603.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      79960..136590 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329039.1 → XP_054185014.1  gamma-tubulin complex component 5 isoform X7

    2. XM_054329038.1 → XP_054185013.1  gamma-tubulin complex component 5 isoform X6

    3. XM_054329037.1 → XP_054185012.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JPW5, A0A0G2JQX1

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187659.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      1543..4302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      20654893..20711463 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377247.1 → XP_054233222.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    2. XM_054377249.1 → XP_054233224.1  gamma-tubulin complex component 5 isoform X4

      UniProtKB/TrEMBL
      A8K1E4
    3. XM_054377248.1 → XP_054233223.1  gamma-tubulin complex component 5 isoform X3

      UniProtKB/TrEMBL
      A8K1E4
    4. XM_054377251.1 → XP_054233226.1  gamma-tubulin complex component 5 isoform X6

    5. XM_054377252.1 → XP_054233227.1  gamma-tubulin complex component 5 isoform X7

    6. XM_054377246.1 → XP_054233221.1  gamma-tubulin complex component 5 isoform X2

      UniProtKB/TrEMBL
      A0A087X1Z1
    7. XM_054377245.1 → XP_054233220.1  gamma-tubulin complex component 5 isoform X1

      UniProtKB/TrEMBL
      A0A087X1Z1
    8. XM_054377250.1 → XP_054233225.1  gamma-tubulin complex component 5 isoform X5

      UniProtKB/TrEMBL
      A8K1E4

    RNA

    1. XR_008488915.1 RNA Sequence

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