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    SPCS2 signal peptidase complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 9789, updated on 10-Dec-2024

    Summary

    Official Symbol
    SPCS2provided by HGNC
    Official Full Name
    signal peptidase complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:28962
    See related
    Ensembl:ENSG00000118363 MIM:619411; AllianceGenome:HGNC:28962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable peptidase activity. Involved in signal peptide processing. Part of signal peptidase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thyroid (RPKM 48.0), prostate (RPKM 34.0) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SPCS2 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (74949266..74979033)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (74878800..74908597)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74660311..74690078)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene X-ray radiation resistance associated 1 Neighboring gene uncharacterized LOC107984352 Neighboring gene ribosomal protein L31 pseudogene 46 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:74644275-74644750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74659504-74660358 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:74660359-74661213 Neighboring gene RNA, U6 small nuclear 216, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5261 Neighboring gene neuraminidase 3 Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of signal peptidase complex subunit 2 homolog (S. cerevisiae; SPCS2) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with signal peptidase complex subunit 2 homolog (SPCS2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ56339, KIAA0102, MGC117366

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in protein targeting to ER  
    involved_in signal peptide processing  
    involved_in signal peptide processing PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane PubMed 
    located_in endoplasmic reticulum membrane  
    part_of signal peptidase complex  
    part_of signal peptidase complex PubMed 

    General protein information

    Preferred Names
    signal peptidase complex subunit 2
    Names
    SPase 25 kDa subunit
    microsomal signal peptidase 25 kDa subunit
    signal peptidase 25kDa subunit
    signal peptidase complex subunit 2 homolog
    NP_055567.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014752.3NP_055567.2  signal peptidase complex subunit 2

      See identical proteins and their annotated locations for NP_055567.2

      Status: VALIDATED

      Source sequence(s)
      AA921960, AP001992, BP338843, D14658
      Consensus CDS
      CCDS44681.1
      UniProtKB/Swiss-Prot
      Q15005, Q15507, Q3KQT0, Q641R4, Q6FG65, Q6IRX0, Q6P1P4, Q96HU9
      UniProtKB/TrEMBL
      B4DDB9
      Related
      ENSP00000263672.6, ENST00000263672.11
      Conserved Domains (1) summary
      pfam06703
      Location:61217
      SPC25; Microsomal signal peptidase 25 kDa subunit (SPC25)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      74949266..74979033
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      74878800..74908597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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