Trappc1 trafficking protein particle complex 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trappc1provided by MGI
Official Full Name: trafficking protein particle complex 1provided by MGI
Primary source: MGI:MGI:1098727
See related: Ensembl:ENSMUSG00000049299 AllianceGenome:MGI:1098727
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BET5; MUM2; D11Ertd172e
Summary: Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPP complex. Is expressed in 1st branchial arch mandibular component; mandible primordium; and neural retina. Orthologous to human TRAPPC1 (trafficking protein particle complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 46.3), CNS E14 (RPKM 38.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.51 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69214812..69216619)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69323986..69325793)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice.
Title: Trappc1 intrinsically prevents ferroptosis of naive T cells to avoid spontaneous autoinflammatory disease in mice.
TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice.
Title: TRAPPC1 is essential for the maintenance and differentiation of common myeloid progenitors in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Ertd172e (e-PCR), detects polymorphism
- UniSTS:167044

NoName (e-PCR)
- UniSTS:493045

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	NAS Non-traceable Author Statement more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle coating	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of TRAPP complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TRAPP complex	IDA Inferred from Direct Assay more info	PubMed
part_of TRAPPII protein complex	NAS Non-traceable Author Statement more info	PubMed
part_of TRAPPIII protein complex	NAS Non-traceable Author Statement more info	PubMed
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: trafficking protein particle complex subunit 1

Names: novel Sybindin-like family domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.