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    Smim10l1 small integral membrane protein 10 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 381820, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Smim10l1provided by MGI
    Official Full Name
    small integral membrane protein 10 like 1provided by MGI
    Primary source
    MGI:MGI:1914379
    See related
    Ensembl:ENSMUSG00000072704 AllianceGenome:MGI:1914379
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700089E24Rik
    Summary
    Orthologous to several human genes including SMIM10L1 (small integral membrane protein 10 like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 16.1), ovary adult (RPKM 5.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Smim10l1 in Genome Data Viewer
    Location:
    6 G1; 6 64.03 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (133082202..133087862)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (133099150..133112089)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17520 Neighboring gene taste receptor, type 2, member 141, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E11338 Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene calmodulin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_17521 Neighboring gene STARR-seq mESC enhancer starr_17522 Neighboring gene RIKEN cDNA 5530400C23 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    small integral membrane protein 10-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163445.2 → NP_001156917.1  small integral membrane protein 10-like protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon structure in the 3' coding region, and differs in the 3' UTR, compared to variant 1. The encoded isoform (3) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122520, AK077261, AW546677
      Consensus CDS
      CCDS51934.1
      UniProtKB/TrEMBL
      A0A087WPM1, E9Q3K4
      Related
      ENSMUSP00000098428.5, ENSMUST00000100864.7
      Conserved Domains (1) summary
      pfam15118
      Location:4 → 67
      DUF4560; Domain of unknown function (DUF4560)

    2. NM_001271582.1 → NP_001258511.1  small integral membrane protein 10-like protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AA048533, AC122520, BB868819
      UniProtKB/TrEMBL
      A0A087WPM1
      Conserved Domains (1) summary
      pfam15118
      Location:4 → 67
      DUF4560; Domain of unknown function (DUF4560)

    3. NM_001271583.1 → NP_001258512.1  small integral membrane protein 10-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA048533, AC122520
      Consensus CDS
      CCDS80626.1
      UniProtKB/TrEMBL
      A0A087WNQ7
      Related
      ENSMUSP00000139452.2, ENSMUST00000191462.2
      Conserved Domains (1) summary
      pfam15118
      Location:4 → 64
      DUF4560; Domain of unknown function (DUF4560)

    RNA

    1. NR_073368.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains two alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA048533, AC122520
      Related
      ENSMUST00000187237.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      133082202..133087862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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