Ipo4 importin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ipo4provided by MGI
Official Full Name: importin 4provided by MGI
Primary source: MGI:MGI:1923001
See related: Ensembl:ENSMUSG00000002319 AllianceGenome:MGI:1923001
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Imp4a; RanBP4; 8430408O15Rik
Summary: Predicted to enable nuclear import signal receptor activity and nuclear localization sequence binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in chromatin. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in retina outer nuclear layer. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 123.0), ovary adult (RPKM 46.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55862857..55873321, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55625400..55635868, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

report a function of IPO4 and nuclear import in the Fanconi anemia pathway of DNA repair
Title: CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.
Metallothionein deficient mice have a marked decrease in Importin 4 transcripts during acute lung injury
Title: The role of metallothionein in the pathogenesis of acute lung injury.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI893436 (e-PCR)
- UniSTS:165907

RH125867 (e-PCR)
- UniSTS:162603

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables nuclear import signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear import signal receptor activity	ISO Inferred from Sequence Orthology more info
enables nuclear import signal receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables nuclear localization sequence binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ribosome biogenesis	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: importin-4

Names: imp4; importin 4a; ran-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360078.1 → NP_001347007.1 importin-4 isoform 2

Status: VALIDATED

Source sequence(s)

AK030490, AK147086, BM950244

Conserved Domains (3) summary

smart00913
Location:24 → 90

IBN_N; Importin-beta N-terminal domain

COG5215
Location:353 → 620

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:353 → 381

HEAT; HEAT repeat [structural motif]
NM_024267.7 → NP_077229.4 importin-4 isoform 1

See identical proteins and their annotated locations for NP_077229.4

Status: VALIDATED

Source sequence(s)

AK030490, AK147086

Consensus CDS

CCDS27121.1

UniProtKB/Swiss-Prot

Q3TBW0, Q8VI75, Q99J52

Related

ENSMUSP00000036555.10, ENSMUST00000047131.16

Conserved Domains (2) summary

smart00913
Location:24 → 90

IBN_N; Importin-beta N-terminal domain

sd00044
Location:353 → 381

HEAT; HEAT repeat [structural motif]

RNA

NR_153401.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK030490, AK147086, BC085150

Related

ENSMUST00000135221.8
NR_153402.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AK018399, AK030490, AK147086

Related

ENSMUST00000148351.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55862857..55873321 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017316220.3 → XP_017171709.1 importin-4 isoform X1

Conserved Domains (2) summary

COG5215
Location:153 → 420

KAP95; Karyopherin (importin) beta [Intracellular trafficking and secretion]

sd00044
Location:153 → 181

HEAT; HEAT repeat [structural motif]