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    TRIB3 tribbles pseudokinase 3 [ Homo sapiens (human) ]

    Gene ID: 57761, updated on 10-Dec-2024

    Summary

    Official Symbol
    TRIB3provided by HGNC
    Official Full Name
    tribbles pseudokinase 3provided by HGNC
    Primary source
    HGNC:HGNC:16228
    See related
    Ensembl:ENSG00000101255 MIM:607898; AllianceGenome:HGNC:16228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIPK; SINK; TRB3; SKIP3; C20orf97
    Summary
    The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Broad expression in thyroid (RPKM 19.9), liver (RPKM 5.0) and 16 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRIB3 in Genome Data Viewer
    Location:
    20p13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (380760..397559)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (424107..440963)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (361404..378203)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12565 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12566 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12567 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12568 Neighboring gene Sharpr-MPRA regulatory region 7859/9812 Neighboring gene SRY-box transcription factor 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:326527-327290 Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:327291-328053 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:328054-328816 Neighboring gene Sharpr-MPRA regulatory region 10349 Neighboring gene Sharpr-MPRA regulatory region 12668 Neighboring gene neurensin 2 Neighboring gene Sharpr-MPRA regulatory region 10396 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:345627-346226 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12572 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12573 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:362523-363521 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:379646-380146 Neighboring gene CRISPRi-validated cis-regulatory element chr20.29 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:386661-386817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12575 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:388888-389530 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:389531-390171 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12576 Neighboring gene RANBP2-type and C3HC4-type zinc finger containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:410614-411114 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:411115-411615 Neighboring gene TBC1 domain family member 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:442560-442708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12577

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Whole genome association scan for genetic polymorphisms influencing information processing speed.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables ubiquitin-protein transferase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of fatty acid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of D-glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tribbles homolog 3
    Names
    TRB-3
    neuronal cell death inducible putative kinase
    p65-interacting inhibitor of NF-kappa-B
    p65-interacting inhibitor of NF-kappaB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301188.1NP_001288117.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288117.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as 1B1) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697937, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
      UniProtKB/TrEMBL
      B4DMM9
      Related
      ENSP00000519697.1, ENST00000714428.1
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    2. NM_001301190.1NP_001288119.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288119.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as 1B2) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697938, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
      UniProtKB/TrEMBL
      B4DMM9
      Related
      ENSP00000519696.1, ENST00000714427.1
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    3. NM_001301193.1NP_001288122.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288122.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also known as 1B3) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697939, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
      UniProtKB/TrEMBL
      B4DMM9
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    4. NM_001301196.1NP_001288125.1  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_001288125.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5, also known as 1B4) has an alternate 5' UTR exon, compared to variant 1. Variants 1, 2, 3, 4 and 5 encode the same isoform 1.
      Source sequence(s)
      AJ697936, AJ697940, BC019363
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
      UniProtKB/TrEMBL
      B4DMM9
      Related
      ENSP00000391873.2, ENST00000449710.6
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    5. NM_001301201.1NP_001288130.1  tribbles homolog 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate 5' UTR exon and an additional exon in the 5' region, which results in an upstream in-frame AUG start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
      Source sequence(s)
      AJ697940, AK297546, BC019363
      Consensus CDS
      CCDS77554.1
      UniProtKB/TrEMBL
      B4DMM9, J3KR25
      Related
      ENSP00000415416.2, ENST00000422053.3
      Conserved Domains (2) summary
      smart00220
      Location:107342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14024
      Location:101342
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3
    6. NM_021158.5NP_066981.2  tribbles homolog 3 isoform 1

      See identical proteins and their annotated locations for NP_066981.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as 1A) represents the longest transcript and encode the predominant isoform (1).
      Source sequence(s)
      AL034548
      Consensus CDS
      CCDS12997.1
      UniProtKB/Swiss-Prot
      Q53GU4, Q53ZW7, Q6I9Y9, Q8TAI6, Q96RU7, Q9H5M8, Q9NUD2
      UniProtKB/TrEMBL
      B4DMM9
      Related
      ENSP00000217233.3, ENST00000217233.9
      Conserved Domains (1) summary
      cd14024
      Location:74315
      PK_TRB3; Pseudokinase domain of Tribbles Homolog 3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      380760..397559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      424107..440963
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)