Kazald1 Kazal-type serine peptidase inhibitor domain 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kazald1provided by MGI
Official Full Name: Kazal-type serine peptidase inhibitor domain 1provided by MGI
Primary source: MGI:MGI:2147606
See related: Ensembl:ENSMUSG00000025213 AllianceGenome:MGI:2147606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bono1; IGFBP-rP10
Summary: Predicted to enable insulin-like growth factor binding activity. Acts upstream of or within extracellular matrix organization. Located in interstitial matrix. Is expressed in several structures, including bone; cap mesenchyme; jaw; nose; and testis. Orthologous to human KAZALD1 (Kazal type serine peptidase inhibitor domain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 22.4), ovary adult (RPKM 14.9) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.32 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (45063404..45067728)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (45074962..45079289)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that IGFBP-rP10 is involved in the proliferation of osteoblasts during bone formation and bone regeneration.
Title: Role of a new member of IGFBP superfamily, IGFBP-rP10, in proliferation and differentiation of osteoblastic cells.
Expression of Bono1 was detected in osteoblasts and secretory odontoblasts by in situ hybridization.
Title: Bono1: a gene associated with regions of deposition of bone and dentine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:488194

AI842353 (e-PCR)
- UniSTS:166156

Kazald1 (e-PCR), detects polymorphism
- UniSTS:461896

NoName (e-PCR)
- UniSTS:237955

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin-like growth factor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in interstitial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kazal-type serine protease inhibitor domain-containing protein 1

Names: IGFBP-related protein 10; Kazal-type serine protease inhibitor domain 1; bone and odontoblast-expressed protein 1; insulin-like growth factor-binding-related protein 10; insulin-like growth factor-binding-related protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362397.1 → NP_001349326.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC132957

UniProtKB/TrEMBL

Q3U2U8

Conserved Domains (3) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain
NM_001362398.1 → NP_001349327.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC132957

Consensus CDS

CCDS29857.1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Related

ENSMUSP00000107579.2, ENSMUST00000111948.8

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]
NM_178929.5 → NP_849260.2 kazal-type serine protease inhibitor domain-containing protein 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_849260.2

Status: VALIDATED

Source sequence(s)

AI842353, AI847274, BB618180, BB869960, BB871162, BC115642

Consensus CDS

CCDS29857.1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Related

ENSMUSP00000026234.5, ENSMUST00000026234.5

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

45063404..45067728

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526567.4 → XP_006526630.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006526630.1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]
XM_030250686.2 → XP_030106546.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]
XM_006526566.3 → XP_006526629.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

See identical proteins and their annotated locations for XP_006526629.1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]
XM_017318042.2 → XP_017173531.1 kazal-type serine protease inhibitor domain-containing protein 1 isoform X1

UniProtKB/Swiss-Prot

Q14BR9, Q8BJ66

UniProtKB/TrEMBL

Q3U2U8

Conserved Domains (4) summary

cd00104
Location:136 → 175

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

pfam00219
Location:61 → 115

IGFBP; Insulin-like growth factor binding protein

pfam07679
Location:179 → 277

I-set; Immunoglobulin I-set domain

cd00096
Location:187 → 190

Ig; Ig strand A' [structural motif]