U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Pxk PX domain containing serine/threonine kinase [ Mus musculus (house mouse) ]

    Gene ID: 218699, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Pxkprovided by MGI
    Official Full Name
    PX domain containing serine/threonine kinaseprovided by MGI
    Primary source
    MGI:MGI:1289230
    See related
    Ensembl:ENSMUSG00000033885 AllianceGenome:MGI:1289230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Slob; Monaka; D14Ertd813e; C230080L11Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; actin binding activity; and phosphatidylinositol binding activity. Involved in modulation of chemical synaptic transmission; negative regulation of ATP-dependent activity; and negative regulation of monoatomic ion transport. Located in cytoplasm and plasma membrane. Part of protein-containing complex. Is expressed in brain and spinal cord. Orthologous to human PXK (PX domain containing serine/threonine kinase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 18.0), placenta adult (RPKM 17.9) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Pxk in Genome Data Viewer
    Location:
    14 A1; 14 4.7 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (14304656..14371593, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (8098180..8165117)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53823 Neighboring gene STARR-seq mESC enhancer starr_35863 Neighboring gene pyruvate dehydrogenase (lipoamide) beta Neighboring gene STARR-positive B cell enhancer mm9_chr14:8946918-8947218 Neighboring gene ribosomal protein L13 pseudogene Neighboring gene ribonuclease P 14 subunit Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene STARR-seq mESC enhancer starr_35858 Neighboring gene STARR-seq mESC enhancer starr_35854 Neighboring gene abhydrolase domain containing 6 Neighboring gene predicted gene, 30244

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. MONaKA, a novel modulator of the plasma membrane Na,K-ATPase. Mao H, et al. J Neurosci, 2005 Aug 31. PMID 16135750, Free PMC Article
    2. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Caenepeel S, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15289607, Free PMC Article
    3. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    4. Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain. Licatalosi DD, et al. Genes Dev, 2012 Jul 15. PMID 22802532, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of ATP-dependent activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of monoatomic ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    PX domain-containing protein kinase-like protein
    Names
    modulator of Na,K-ATPase

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360313.1 → NP_001347242.1  PX domain-containing protein kinase-like protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK150660, AK153067, AW455875
      Consensus CDS
      CCDS88565.1
      UniProtKB/TrEMBL
      A0A2C9F2B5
      Related
      ENSMUSP00000035265.9, ENSMUST00000036682.9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 482
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    2. NM_001360314.1 → NP_001347243.1  PX domain-containing protein kinase-like protein short isoform

      Status: VALIDATED

      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875, CT573024
      Consensus CDS
      CCDS36799.1
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    3. NM_001360315.1 → NP_001347244.1  PX domain-containing protein kinase-like protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK150660, AK153067, AW455875, BM945330, CT573024
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 482
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    4. NM_001360316.1 → NP_001347245.1  PX domain-containing protein kinase-like protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875, CT573024

    5. NM_145458.4 → NP_663433.2  PX domain-containing protein kinase-like protein long isoform

      See identical proteins and their annotated locations for NP_663433.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (L) encodes the longest isoform.
      Source sequence(s)
      AK150337, AK150660, AK153067, AW455875
      Consensus CDS
      CCDS26810.1
      UniProtKB/Swiss-Prot
      Q3TD60, Q3TEL7, Q3TZZ1, Q3U197, Q3U773, Q3UCS5, Q4FBH7, Q8BX57, Q91WB6
      Related
      ENSMUSP00000152987.2, ENSMUST00000225653.2
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    6. NM_178279.3 → NP_840063.1  PX domain-containing protein kinase-like protein short isoform

      See identical proteins and their annotated locations for NP_840063.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (S) uses an alternate splice site in the 3' coding region, compared to variant L. The resulting protein is shorter and has a distinct C-terminus, when compared to the longer isoform.
      Source sequence(s)
      AK150660, AK153067, AW455875, BM945330, CT573024
      Consensus CDS
      CCDS36799.1
      UniProtKB/Swiss-Prot
      Q8BX57
      Related
      ENSMUSP00000108309.3, ENSMUST00000112689.9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      14304656..14371593 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517982.3 → XP_006518045.1  PX domain-containing protein kinase-like protein isoform X7

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    2. XM_006517977.4 → XP_006518040.1  PX domain-containing protein kinase-like protein isoform X2

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    3. XM_030247724.1 → XP_030103584.1  PX domain-containing protein kinase-like protein isoform X5

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    4. XM_006517980.3 → XP_006518043.1  PX domain-containing protein kinase-like protein isoform X6

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    5. XM_006517975.4 → XP_006518038.1  PX domain-containing protein kinase-like protein isoform X1

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    6. XM_006517978.4 → XP_006518041.1  PX domain-containing protein kinase-like protein isoform X4

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    7. XM_036158542.1 → XP_036014435.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465 → 495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    8. XM_036158540.1 → XP_036014433.1  PX domain-containing protein kinase-like protein isoform X8

      Conserved Domains (3) summary
      cd22062
      Location:466 → 496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    9. XM_036158541.1 → XP_036014434.1  PX domain-containing protein kinase-like protein isoform X8

      Conserved Domains (3) summary
      cd22062
      Location:466 → 496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    10. XM_030247727.1 → XP_030103587.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465 → 495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    11. XM_030247728.1 → XP_030103588.1  PX domain-containing protein kinase-like protein isoform X10

      Conserved Domains (2) summary
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    12. XM_006517984.2 → XP_006518047.1  PX domain-containing protein kinase-like protein isoform X8

      See identical proteins and their annotated locations for XP_006518047.1

      Conserved Domains (3) summary
      cd22062
      Location:466 → 496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    13. XM_030247726.1 → XP_030103586.1  PX domain-containing protein kinase-like protein isoform X9

      Conserved Domains (3) summary
      cd22062
      Location:465 → 495
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    14. XM_006517985.2 → XP_006518048.1  PX domain-containing protein kinase-like protein isoform X8

      See identical proteins and their annotated locations for XP_006518048.1

      Conserved Domains (3) summary
      cd22062
      Location:466 → 496
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    15. XM_017315951.2 → XP_017171440.1  PX domain-containing protein kinase-like protein isoform X6

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    16. XM_017315949.2 → XP_017171438.1  PX domain-containing protein kinase-like protein isoform X3

      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    RNA

    1. XR_874027.3 RNA Sequence

    2. XR_001781106.2 RNA Sequence

    3. XR_004938378.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BX57.2 GenPept UniProtKB/Swiss-Prot:Q8BX57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools