Rusc1 RUN and SH3 domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rusc1provided by MGI
Official Full Name: RUN and SH3 domain containing 1provided by MGI
Primary source: MGI:MGI:1919546
See related: Ensembl:ENSMUSG00000041263 AllianceGenome:MGI:1919546
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NESCA; 2210403N08Rik
Summary: Enables actin binding activity. Predicted to be involved in protein polyubiquitination. Located in Golgi apparatus; early endosome; and microtubule cytoskeleton. Is expressed in gut; nervous system; and sensory organ. Orthologous to human RUSC1 (RUN and SH3 domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 26.5), CNS E18 (RPKM 25.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 39.01 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88991282..89000670, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (89083975..89093363, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nesca functions as an adapter involved in neuronal vesicular transport
Title: Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre-synaptic membrane protein, syntaxin-1, in hippocampal neurons.
Data suggest that Nesca serves a novel, nuclear-dependent role in neurotrophin-dependent neurite outgrowth.
Title: Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW534365 (e-PCR)
- UniSTS:246568

AA408288 (e-PCR)
- UniSTS:159138

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: AP-4 complex accessory subunit RUSC1

Names: RUN and SH3 domain-containing protein 1; new molecule containing SH3 at the carboxy-terminus

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083807.2 → NP_001077276.1 AP-4 complex accessory subunit RUSC1 isoform 2

See identical proteins and their annotated locations for NP_001077276.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC140468

Consensus CDS

CCDS38485.1

UniProtKB/Swiss-Prot

Q6PHT9, Q8BG26

Related

ENSMUSP00000056640.7, ENSMUST00000052539.13

Conserved Domains (2) summary

pfam02759
Location:523 → 633

RUN; RUN domain

cl17036
Location:839 → 890

SH3; Src Homology 3 domain superfamily
NM_001083808.2 → NP_001077277.1 AP-4 complex accessory subunit RUSC1 isoform 3

See identical proteins and their annotated locations for NP_001077277.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC140468

Consensus CDS

CCDS50956.1

UniProtKB/TrEMBL

Q3TDG5

Related

ENSMUSP00000130477.2, ENSMUST00000166687.6

Conserved Domains (2) summary

cl02689
Location:61 → 171

RUN; RUN domain

cl17036
Location:377 → 428

SH3; Src Homology 3 domain superfamily
NM_001429159.1 → NP_001416088.1 AP-4 complex accessory subunit RUSC1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation from a downstream ATG and an isoform (3) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC140468

UniProtKB/TrEMBL

Q3TDG5
NM_028188.3 → NP_082464.2 AP-4 complex accessory subunit RUSC1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC140468

Consensus CDS

CCDS38486.1

UniProtKB/Swiss-Prot

Q8BG26

Related

ENSMUSP00000088447.6, ENSMUST00000090929.12

Conserved Domains (2) summary

pfam02759
Location:660 → 770

RUN; RUN domain

cl17036
Location:976 → 1027

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

88991282..89000670 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502134.5 → XP_006502197.1 AP-4 complex accessory subunit RUSC1 isoform X1

Conserved Domains (2) summary

cl02689
Location:61 → 171

RUN; RUN domain

cl17036
Location:377 → 428

SH3; Src Homology 3 domain superfamily