Hic1 hypermethylated in cancer 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hic1provided by MGI
Official Full Name: hypermethylated in cancer 1provided by MGI
Primary source: MGI:MGI:1338010
See related: Ensembl:ENSMUSG00000043099 AllianceGenome:MGI:1338010
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HIC-1
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and sequence-specific double-stranded DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA damage response, signal transduction by p53 class mediator. Located in chromatin. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and trophectoderm. Used to study Miller-Dieker lissencephaly syndrome. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 27.9), limb E14.5 (RPKM 25.0) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.76 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75052203..75059970, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75161377..75170255, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103[+] intestine-resident memory CD8[+] T cells.
Title: T-bet deficiency and Hic1 induction override TGF-β-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells.
Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.
Title: Nmnat1 Deficiency Causes Mitoribosome Excess in Diabetic Nephropathy Mediated by Transcriptional Repressor HIC1.
HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
Title: HIC1 Represses Atoh1 Transcription and Hair Cell Differentiation in the Cochlea.
Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Title: Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.
Loss of HIC1 in KrasG12D/+(Lox-Stop-Lox)/sgHIC1 mice could promote tumorigenesis.
Title: Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression.
Loss of Hic1 expression in the early stages of tumor formation may contribute to malignant transformation through the acquisition of chromosomal instability.
Title: The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53.
Intestinal innate lymphoid cells express HIC1 in a vitamin A-dependent manner.
Title: HIC1 links retinoic acid signalling to group 3 innate lymphoid cell-dependent regulation of intestinal immunity and homeostasis.
this study identified a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions
Title: The transcriptional repressor HIC1 regulates intestinal immune homeostasis.
HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
Title: HIC1 loss promotes prostate cancer metastasis by triggering epithelial-mesenchymal transition.
identify HIC1 as the first transcription factor in mammals able to recruit PRC2 to some target promoters through its interaction with Polycomb-like proteins.
Title: Hypermethylated in cancer 1 (HIC1) recruits polycomb repressive complex 2 (PRC2) to a subset of its target genes through interaction with human polycomb-like (hPCL) proteins.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126523 (e-PCR)
- UniSTS:208703

Hic1 (e-PCR), detects polymorphism
- UniSTS:498503

Hic1 (e-PCR), detects polymorphism
- UniSTS:143344

RH124699 (e-PCR)
- UniSTS:161521

G54872 (e-PCR)
- UniSTS:164090

G54864 (e-PCR)
- UniSTS:164094

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hypermethylated in cancer 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098203.1 → NP_001091673.1 hypermethylated in cancer 1 protein isoform 2

See identical proteins and their annotated locations for NP_001091673.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' terminal exon including the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AL603905, BU757195, CJ126522

UniProtKB/Swiss-Prot

B1ARH0, Q9R1Y5, Q9R1Y6, Q9R2B0

Related

ENSMUSP00001091661.1, ENSMUST00000131720.3

Conserved Domains (6) summary

smart00225
Location:48 → 152

BTB; Broad-Complex, Tramtrack and Bric a brac

COG5048
Location:561 → 609

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:537 → 557

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:535 → 557

zf-C2H2; Zinc finger, C2H2 type

pfam00651
Location:37 → 150

BTB; BTB/POZ domain

pfam13465
Location:578 → 602

zf-H2C2_2; Zinc-finger double domain
NM_010430.3 → NP_034560.3 hypermethylated in cancer 1 protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AL603905

Consensus CDS

CCDS36226.1

UniProtKB/TrEMBL

Z4YJP0

Related

ENSMUSP00000053483.6, ENSMUST00000055619.6

Conserved Domains (5) summary

COG5048
Location:482 → 594

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:518 → 538

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18333
Location:7 → 136

BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

pfam00096
Location:516 → 538

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:558 → 583

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

75052203..75059970 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532275.3 → XP_006532338.1 hypermethylated in cancer 1 protein isoform X1

UniProtKB/TrEMBL

Z4YJP0

Conserved Domains (5) summary

COG5048
Location:482 → 594

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:518 → 538

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18333
Location:7 → 136

BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

pfam00096
Location:516 → 538

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:558 → 583

zf-H2C2_2; Zinc-finger double domain