Ptpa protein phosphatase 2 protein activator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptpaprovided by MGI
Official Full Name: protein phosphatase 2 protein activatorprovided by MGI
Primary source: MGI:MGI:1346006
See related: Ensembl:ENSMUSG00000039515 AllianceGenome:MGI:1346006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PR53; Ppp2r4; 2610042B21Rik
Summary: Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in subcutaneous fat pad adult (RPKM 63.8), liver E14.5 (RPKM 52.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.71 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30306062..30337819)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30416050..30447807)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
Title: PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
results implicate a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggest that PP2A-based drugs could be potential therapeutic candidates for treatment of UBE3A-related disorders
Title: UBE3A-mediated PTPA ubiquitination and degradation regulate PP2A activity and dendritic spine morphology.
Evidence for PPP2R4 as a haploinsufficient tumor suppressor gene, defining a high-penetrance genetic mechanism for PP2A inhibition in human cancer.
Title: PP2A Inactivation Mediated by PPP2R4 Haploinsufficiency Promotes Cancer Development.
data indicate that PTPalpha and FAK, which are enriched in FAs, interact with IP3R1 at adjacent ER sites to spatially sequester IL-1-induced Ca(2+) signalling
Title: A ternary complex comprising FAK, PTPα and IP3 receptor 1 functionally engages focal adhesions and the endoplasmic reticulum to mediate IL-1-induced Ca2+ signalling in fibroblasts.
oxidative stress regulates the phosphorylation status of nonribosomal rpS3 by both activating PKCdelta and blocking the PP2A interaction with rpS3
Title: Phosphorylation status of nuclear ribosomal protein S3 is reciprocally regulated by protein kinase C{delta} and protein phosphatase 2A.
findings show that ectopic expression of the phosphotyrosyl phosphatase activator PTPA induces cell death in mammalian cells via a mechanism involving caspase-3-dependent apoptosis
Title: Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127941 (e-PCR)
- UniSTS:211251

RH126164 (e-PCR)
- UniSTS:162875

RH125061 (e-PCR)
- UniSTS:161883

REN36142 (e-PCR)
- UniSTS:360942

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
contributes_to phosphoprotein phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activator activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ATPase complex	ISO Inferred from Sequence Orthology more info
part_of ATPase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 2A complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 2A complex	ISO Inferred from Sequence Orthology more info
part_of protein phosphatase type 2A complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2A activator

Names: phosphotyrosyl phosphatase activator; protein phosphatase 2A activator, regulatory subunit B; protein phosphatase 2A, regulatory subunit B (PR 53); serine/threonine-protein phosphatase 2A regulatory subunit 4; serine/threonine-protein phosphatase 2A regulatory subunit B'

NP_001349662.1

EC 5.2.1.8

NP_001349663.1

EC 5.2.1.8

NP_620087.3

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362733.1 → NP_001349662.1 serine/threonine-protein phosphatase 2A activator isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AL954299

UniProtKB/TrEMBL

Q8C0E1

Conserved Domains (1) summary

pfam03095
Location:26 → 319

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
NM_001362734.1 → NP_001349663.1 serine/threonine-protein phosphatase 2A activator isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL954299

Conserved Domains (1) summary

pfam03095
Location:26 → 229

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
NM_138748.5 → NP_620087.3 serine/threonine-protein phosphatase 2A activator isoform 2

See identical proteins and their annotated locations for NP_620087.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK049184, AL954299

Consensus CDS

CCDS15883.1

UniProtKB/Swiss-Prot

P58389

UniProtKB/TrEMBL

Q543N6, Q8C0E1

Related

ENSMUSP00000046837.4, ENSMUST00000042055.10

Conserved Domains (1) summary

pfam03095
Location:26 → 316

PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

RNA

NR_156126.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL954299
NR_156127.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL954299, CX221557