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    Spag7 sperm associated antigen 7 [ Mus musculus (house mouse) ]

    Gene ID: 216873, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Spag7provided by MGI
    Official Full Name
    sperm associated antigen 7provided by MGI
    Primary source
    MGI:MGI:107380
    See related
    Ensembl:ENSMUSG00000018287 AllianceGenome:MGI:107380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ACRP; FSA-1; Fsa1l; 5730443G10
    Summary
    Predicted to enable nucleic acid binding activity. Predicted to be located in nucleus. Orthologous to human SPAG7 (sperm associated antigen 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 44.1), CNS E11.5 (RPKM 38.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Spag7 in Genome Data Viewer
    Location:
    11 B3; 11 43.21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70554595..70560242, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70663769..70669416, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1422 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70460970-70461079 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70461301-70461410 Neighboring gene solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11 Neighboring gene STARR-positive B cell enhancer ABC_E7008 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70465643-70465931 Neighboring gene ring finger protein 167 Neighboring gene STARR-positive B cell enhancer ABC_E3969 Neighboring gene profilin 1 Neighboring gene enolase 3, beta muscle Neighboring gene STARR-positive B cell enhancer ABC_E62 Neighboring gene calmodulin binding transcription activator 2 Neighboring gene inhibitor of CDK, cyclin A1 interacting protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7009 Neighboring gene kinesin family member 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a fox sperm protein FSA-1. Beaton S, et al. Reprod Fertil Dev, 1994. PMID 7624517
    2. SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction. Flaherty SE 3rd, et al. Elife, 2024 Jul 26. PMID 39056292, Free PMC Article
    3. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11. Watters JW, et al. Genomics, 2001 Apr 15. PMID 11318612
    4. Gene expression in pharyngeal arch 1 during human embryonic development. Cai J, et al. Hum Mol Genet, 2005 Apr 1. PMID 15703188
    5. Identification of genes contributing to the obese yellow Avy phenotype: caloric restriction, genotype, diet x genotype interactions. Kaput J, et al. Physiol Genomics, 2004 Aug 11. PMID 15306695

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC67704

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sperm-associated antigen 7

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167669.1 → NP_001161141.1  sperm-associated antigen 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini, as compared to isoform 1.
      Source sequence(s)
      AK042294, AL596117, AV122139, BY261455
      UniProtKB/Swiss-Prot
      Q7TNE3
      Conserved Domains (1) summary
      cd02636
      Location:52 → 99
      R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...

    2. NM_172561.3 → NP_766149.2  sperm-associated antigen 7 isoform 1

      See identical proteins and their annotated locations for NP_766149.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK042294, AL596117, AV122139
      Consensus CDS
      CCDS24962.1
      UniProtKB/Swiss-Prot
      Q3TM27, Q7TNE3, Q80XJ8, Q8BK16
      Related
      ENSMUSP00000018431.7, ENSMUST00000018431.13
      Conserved Domains (1) summary
      cd02636
      Location:49 → 109
      R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70554595..70560242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156575.1 → XP_036012468.1  sperm-associated antigen 7 isoform X1

      Conserved Domains (1) summary
      cd02636
      Location:1 → 58
      R3H_sperm-antigen; R3H domain of a group of metazoan proteins that is related to the sperm-associated antigen 7. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TNE3.1 GenPept UniProtKB/Swiss-Prot:Q7TNE3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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