DCUN1D2 defective in cullin neddylation 1 domain containing 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DCUN1D2provided by HGNC
Official Full Name: defective in cullin neddylation 1 domain containing 2provided by HGNC
Primary source: HGNC:HGNC:20328
See related: Ensembl:ENSG00000150401 AllianceGenome:HGNC:20328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DCNL2; C13orf17
Summary: Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart (RPKM 8.1), testis (RPKM 2.5) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q34

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (113455819..113491563, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (112714662..112750406, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (114110134..114145026, complement)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13S1005 (e-PCR)
- UniSTS:152338

D8S2279 (e-PCR)
- UniSTS:473907

D10S16 (e-PCR)
- UniSTS:155756

A008R23 (e-PCR)
- UniSTS:75410

RH45055 (e-PCR)
- UniSTS:78829

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cullin family protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables cullin family protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein neddylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein neddylation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DCN1-like protein 2

Names: DCN1, defective in cullin neddylation 1, domain containing 2; DCUN1 domain-containing protein 2; defective in cullin neddylation protein 1-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014283.2 → NP_001014305.1 DCN1-like protein 2

See identical proteins and their annotated locations for NP_001014305.1

Status: VALIDATED

Source sequence(s)

AK000099, AK001566, AL442125, BM836766

Consensus CDS

CCDS32013.1

UniProtKB/Swiss-Prot

Q5JSA5, Q5JSA6, Q5JSA7, Q6PH85, Q9NVJ1, Q9NXR6

Related

ENSP00000417706.1, ENST00000478244.6

Conserved Domains (2) summary

cd14412
Location:2 → 48

UBA_DCNL2; UBA-like domain found in DCN1-like protein 2 (DCNL2) and similar proteins

pfam03556
Location:136 → 246

Cullin_binding; Cullin binding

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000013.11 Reference GRCh38.p14 Primary Assembly

Range

113455819..113491563 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017020647.2 → XP_016876136.1 DCN1-like protein 2 isoform X2

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 33

UBA_like_SF; UBA domain-like superfamily
XM_017020649.2 → XP_016876138.2 DCN1-like protein 2 isoform X3

Related

ENSP00000330629.3, ENST00000332592.7
XM_017020644.2 → XP_016876133.1 DCN1-like protein 2 isoform X2

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 33

UBA_like_SF; UBA domain-like superfamily
XM_017020643.2 → XP_016876132.1 DCN1-like protein 2 isoform X1
XM_017020646.3 → XP_016876135.1 DCN1-like protein 2 isoform X2

Conserved Domains (2) summary

pfam03556
Location:121 → 231

Cullin_binding; Cullin binding

cl21463
Location:1 → 33

UBA_like_SF; UBA domain-like superfamily
XM_047430432.1 → XP_047286388.1 DCN1-like protein 2 isoform X2
XM_047430431.1 → XP_047286387.1 DCN1-like protein 2 isoform X2

RNA

XR_007063687.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060937.1 Alternate T2T-CHM13v2.0

Range

112714662..112750406 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054374656.1 → XP_054230631.1 DCN1-like protein 2 isoform X2
XM_054374657.1 → XP_054230632.1 DCN1-like protein 2 isoform X3
XM_054374654.1 → XP_054230629.1 DCN1-like protein 2 isoform X2
XM_054374651.1 → XP_054230626.1 DCN1-like protein 2 isoform X1
XM_054374655.1 → XP_054230630.1 DCN1-like protein 2 isoform X2
XM_054374653.1 → XP_054230628.1 DCN1-like protein 2 isoform X2
XM_054374652.1 → XP_054230627.1 DCN1-like protein 2 isoform X2

RNA

XR_008488769.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_018185.2: Suppressed sequence

Description

NM_018185.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.