Fcgrt Fc fragment of IgG receptor and transporter [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fcgrtprovided by MGI
Official Full Name: Fc fragment of IgG receptor and transporterprovided by MGI
Primary source: MGI:MGI:103017
See related: Ensembl:ENSMUSG00000003420 AllianceGenome:MGI:103017
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: FcRn
Summary: Predicted to enable IgG binding activity and beta-2-microglobulin binding activity. Predicted to be involved in immune response. Predicted to be located in endosome membrane and plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including genitourinary system; heart valve; intestine; sensory organ; and skeleton. Orthologous to human FCGRT (Fc gamma receptor and transporter). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in placenta adult (RPKM 121.9), mammary gland adult (RPKM 87.9) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 29.12 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44742417..44753246, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (45092993..45103822, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.
Title: Identification of Four Mouse FcRn Splice Variants and FcRn-Specific Vesicles.
Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
Title: Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity.
Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
Title: Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes.
Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
Title: Dynamics of intracellular neonatal Fc receptor-ligand interactions in primary macrophages using biophysical fluorescence techniques.
Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
Title: Podocyte-specific knockout of the neonatal Fc receptor (FcRn) results in differential protection depending on the model of glomerulonephritis.
FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
Title: FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.
In podocytes, Fcgrt modulates the IL-6 mediated response to inflammatory stimuli and regulates podocytes actin structure.
Title: Knockout of the neonatal Fc receptor in cultured podocytes alters IL-6 signaling and the actin cytoskeleton.
The studies demonstrate a pivotal role for FcRn-mediated salvage in compensating for the high pinocytic and degradative activities of macrophages to maintain IgG homeostasis.
Title: Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis.
Knockout of FcRn leads to IgG accumulation in podocytes but does not alter albumin trafficking.
Title: Differential trafficking of albumin and IgG facilitated by the neonatal Fc receptor in podocytes in vitro and in vivo.
These findings support the critical role of FcRn downregulation in the tumor microenvironment in anti-tumor immunity, via NK cell maturation and activation.
Title: Lack of FcRn Impairs Natural Killer Cell Development and Functions in the Tumor Microenvironment.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10)
Targeted (4) 1 citation

General gene information

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Markers

D37874 (e-PCR)
- UniSTS:179567

Fcgrt (e-PCR), detects polymorphism
- UniSTS:256667

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables IgG binding	IEA Inferred from Electronic Annotation more info
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables beta-2-microglobulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-2-microglobulin binding	ISO Inferred from Sequence Orthology more info
NOT enables peptide antigen binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: IgG receptor FcRn large subunit p51

Names: Fc receptor, IgG, alpha chain transporter; igG Fc fragment receptor transporter alpha chain; neonatal Fc receptor; neonatal fragment crystallizable Fc receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357117.1 → NP_001344046.1 IgG receptor FcRn large subunit p51 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC126256

Consensus CDS

CCDS90230.1

UniProtKB/TrEMBL

Q6PKB0

Related

ENSMUSP00000147496.2, ENSMUST00000210642.2

Conserved Domains (2) summary

cl08246
Location:25 → 201

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:205 → 292

Ig; Immunoglobulin domain
NM_010189.3 → NP_034319.2 IgG receptor FcRn large subunit p51 isoform 1 precursor

See identical proteins and their annotated locations for NP_034319.2

Status: VALIDATED

Source sequence(s)

AK146933, AK152879, BY063885

Consensus CDS

CCDS52243.1

UniProtKB/Swiss-Prot

Q61559, Q9QUR0, Q9R2A5

Related

ENSMUSP00000003512.8, ENSMUST00000003512.9

Conserved Domains (2) summary

cl08246
Location:25 → 197

MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

cl11960
Location:201 → 288

Ig; Immunoglobulin domain