Dmc1 DNA meiotic recombinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmc1provided by MGI
Official Full Name: DNA meiotic recombinase 1provided by MGI
Primary source: MGI:MGI:105393
See related: Ensembl:ENSMUSG00000022429 AllianceGenome:MGI:105393
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sgdp; Dmc1h; Lim15; Mei11
Summary: This gene encodes a member of the superfamily of recombinases (also called DNA strand-exchange proteins). Recombinases are important for repairing double-strand DNA breaks during mitosis and meiosis. This protein, which is evolutionarily conserved, is reported to be essential for meiotic homologous recombination and may thus play an important role in generating diversity of genetic information. In mouse, deficiency of this gene causes infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Expression: Biased expression in limb E14.5 (RPKM 2.8), testis adult (RPKM 2.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.79 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79445698..79489362, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79561497..79605159, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
Title: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination.
The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
Title: The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates.
Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase.
Title: Super-resolution imaging of RAD51 and DMC1 in DNA repair foci reveals dynamic distribution patterns in meiotic prophase.
In this study, we created a mouse model of a putative infertility allele, DMC1M200V. DMC1 encodes a RecA homolog essential for meiotic recombination and fertility in mice..we found that Dmc1M200V/M200V male and female mice are fully fertile and do not exhibit any gonadal abnormalities
Title: A putative human infertility allele of the meiotic recombinase DMC1 does not affect fertility in mice.
we observed the occurrence of synaptonemal complex bridges between bivalents, most likely representing chromosome translocation events that may involve DMC1, RAD51 or 53BP1.
Title: Transition from a meiotic to a somatic-like DNA damage response during the pachytene stage in mouse meiosis.
The DMC1 was highly variable from cell to cell, whereas foci of the crossover marker MLH1 showed little variability.
Title: Homeostatic control of recombination is implemented progressively in mouse meiosis.
RAD51AP1 foci colocalize with a subset of DMC1 foci in spermatocytes.
Title: Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1).
Dmc1(Mei11) exposes a sex difference in recombination in that a significant portion of female oocytes can compensate for DMC1 deficiency to undergo crossing-over and complete gametogenesis.
Title: A dominant, recombination-defective allele of Dmc1 causing male-specific sterility.
Mei1 can be positioned upstream of Dmc1 in the genetic pathway that operates during mammalian meiosis
Title: Mei1 is epistatic to Dmc1 during mouse meiosis.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (other) (1) 1 citation
Endonuclease-mediated (3) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491306

Dmc1 (e-PCR), detects polymorphism
- UniSTS:471174

Dmc1 (e-PCR), detects polymorphism
- UniSTS:525708

D15Mit259 (e-PCR), detects polymorphism
- UniSTS:127630

D15Mit71 (e-PCR), detects polymorphism
- UniSTS:127693

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent DNA damage sensor activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent activity, acting on DNA	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent activity, acting on DNA	ISO Inferred from Sequence Orthology more info
enables DNA strand exchange activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA strand exchange activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA strand exchange activity	ISS Inferred from Sequence or Structural Similarity more info
enables double-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables single-stranded DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA recombinase assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA strand invasion	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome organization involved in meiotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair involved in meiotic recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in double-strand break repair via homologous recombination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gamete generation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homologous chromosome pairing at meiosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IDA Inferred from Direct Assay more info	PubMed
involved_in reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info
involved_in reciprocal meiotic recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
is_active_in condensed nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: meiotic recombination protein DMC1/LIM15 homolog

Names: DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination; disrupted meiotic cDNA 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278226.1 → NP_001265155.1 meiotic recombination protein DMC1/LIM15 homolog isoform 2

See identical proteins and their annotated locations for NP_001265155.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 2) lacks an internal portion and is shorter, compared to isoform 1.

Source sequence(s)

AK076777, AK169570, AV451479

Consensus CDS

CCDS88806.1

UniProtKB/TrEMBL

Q8C610

Related

ENSMUSP00000155228.2, ENSMUST00000229408.2

Conserved Domains (3) summary

TIGR02238
Location:24 → 283

recomb_DMC1; meiotic recombinase Dmc1

cd01123
Location:101 → 281

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam14520
Location:25 → 79

HHH_5; Helix-hairpin-helix domain
NM_010059.3 → NP_034189.1 meiotic recombination protein DMC1/LIM15 homolog isoform 1

See identical proteins and their annotated locations for NP_034189.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).

Source sequence(s)

AK169570, AV451479, BC116767

Consensus CDS

CCDS27644.1

UniProtKB/Swiss-Prot

Q61880

UniProtKB/TrEMBL

Q14AN8

Related

ENSMUSP00000023065.7, ENSMUST00000023065.8

Conserved Domains (3) summary

TIGR02238
Location:24 → 338

recomb_DMC1; meiotic recombinase Dmc1

cd01123
Location:101 → 336

Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...

pfam14520
Location:25 → 79

HHH_5; Helix-hairpin-helix domain

RNA

NR_103477.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks five alternate internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK169570, AV451479

Related

ENSMUST00000230011.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79445698..79489362 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520407.4 → XP_006520470.1 meiotic recombination protein DMC1/LIM15 homolog isoform X1

Conserved Domains (1) summary

TIGR02238
Location:24 → 296

recomb_DMC1; meiotic recombinase Dmc1
XM_006520408.4 → XP_006520471.1 meiotic recombination protein DMC1/LIM15 homolog isoform X2

Conserved Domains (1) summary

TIGR02238
Location:24 → 282

recomb_DMC1; meiotic recombinase Dmc1