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    Folr1 folate receptor alpha [ Mus musculus (house mouse) ]

    Gene ID: 14275, updated on 27-Nov-2024

    Summary

    Official Symbol
    Folr1provided by MGI
    Official Full Name
    folate receptor alphaprovided by MGI
    Primary source
    MGI:MGI:95568
    See related
    Ensembl:ENSMUSG00000001827 AllianceGenome:MGI:95568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBP1; Folbp1; Folbp-1
    Summary
    Predicted to enable folic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Folr1 in Genome Data Viewer
    Location:
    7 E2; 7 54.67 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101507551..101519974, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101858331..101870788, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene predicted gene 10602 Neighboring gene folate receptor beta Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597 Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene transmembrane O-methyltransferase

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables folic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables folic acid binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables folic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables folic acid receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables folic acid receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterior neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to folic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to folic acid ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within folic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in folic acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in folic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neural crest cell migration involved in heart formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pharyngeal arch artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to axon injury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sperm-egg recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in clathrin-coated vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    folate receptor alpha
    Names
    FR-alpha
    folate receptor 1 (adult)
    folate-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252552.2NP_001239481.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239481.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.
      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Related
      ENSMUSP00000102598.2, ENSMUST00000106985.8
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    2. NM_001252553.2NP_001239482.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239482.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    3. NM_001252554.2NP_001239483.1  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_001239483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Related
      ENSMUSP00000102596.2, ENSMUST00000106983.8
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    4. NM_001412428.1NP_001399357.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    5. NM_001412429.1NP_001399358.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    6. NM_001412430.1NP_001399359.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    7. NM_001412431.1NP_001399360.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    8. NM_001412432.1NP_001399361.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    9. NM_001412433.1NP_001399362.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    10. NM_001412434.1NP_001399363.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    11. NM_001412435.1NP_001399364.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    12. NM_001412436.1NP_001399365.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      Related
      ENSMUSP00000102595.2, ENSMUST00000106982.8
    13. NM_001412437.1NP_001399366.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    14. NM_001412438.1NP_001399367.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
    15. NM_001412439.1NP_001399368.1  folate receptor alpha precursor

      Status: VALIDATED

      Source sequence(s)
      AC167240
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      Related
      ENSMUSP00000102594.2, ENSMUST00000106981.8
    16. NM_008034.4NP_032060.2  folate receptor alpha precursor

      See identical proteins and their annotated locations for NP_032060.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
      Source sequence(s)
      AC167240
      Consensus CDS
      CCDS21517.1
      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Related
      ENSMUSP00000102599.3, ENSMUST00000106986.9
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      101507551..101519974 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507369.3XP_006507432.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507432.1

      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    2. XM_006507366.4XP_006507429.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507429.1

      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    3. XM_006507364.4XP_006507427.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507427.1

      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family
    4. XM_006507367.5XP_006507430.1  folate receptor alpha isoform X1

      See identical proteins and their annotated locations for XP_006507430.1

      UniProtKB/Swiss-Prot
      P35846, Q9R222
      UniProtKB/TrEMBL
      A1A4B2
      Conserved Domains (1) summary
      pfam03024
      Location:34209
      Folate_rec; Folate receptor family