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    Npas1 neuronal PAS domain protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 18142, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Npas1provided by MGI
    Official Full Name
    neuronal PAS domain protein 1provided by MGI
    Primary source
    MGI:MGI:109205
    See related
    Ensembl:ENSMUSG00000001988 AllianceGenome:MGI:109205
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOP5; bHLHe11
    Summary
    Enables protein heterodimerization activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within maternal behavior; negative regulation of transcription by RNA polymerase II; and startle response. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; lung; and nervous system. Orthologous to human NPAS1 (neuronal PAS domain protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.5), cortex adult (RPKM 2.8) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Npas1 in Genome Data Viewer
    Location:
    7 A2; 7 9.14 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16189643..16210741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16455721..16476822, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene zinc finger CCCH-type containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160 Neighboring gene nuclear encoded rRNA 5S 151 Neighboring gene STARR-positive B cell enhancer ABC_E10425 Neighboring gene Rho GTPase activating protein 35 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 17981

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons. Morais-Silva G, et al. J Neurosci, 2023 Jan 18. PMID 36443000, Free PMC Article
    2. Neuronal PAS domain protein 1 is a transcriptional repressor and requires arylhydrocarbon nuclear translocator for its nuclear localization. Teh CH, et al. J Biol Chem, 2006 Nov 10. PMID 16954219
    3. Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons. Teh CH, et al. J Neurosci Res, 2007 Jun. PMID 17457889
    4. NPAS1 regulates branching morphogenesis in embryonic lung. Levesque BM, et al. Am J Respir Cell Mol Biol, 2007 Apr. PMID 17110583, Free PMC Article
    5. Parvalbumin(+) and Npas1(+) Pallidal Neurons Have Distinct Circuit Topology and Function. Pamukcu A, et al. J Neurosci, 2020 Oct 7. PMID 32868462, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.
      Title: Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons.
    2. Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
      Title: Striatal Direct Pathway Targets Npas1(+) Pallidal Neurons.
    3. Parvalbumin(+) and Npas1(+) Pallidal Neurons Have Distinct Circuit Topology and Function.
      Title: Parvalbumin(+) and Npas1(+) Pallidal Neurons Have Distinct Circuit Topology and Function.
    4. Study provides a clear, unbiased view of the full spectrum of genes regulated by NPAS1 and NPAS3 and shows that these transcription factors are master regulators of neuropsychiatric function. These findings expose the molecular pathophysiology of NPAS1/3 mutations and provide a striking example of the shared, combinatorial nature of molecular pathways that underlie diagnostically distinct neuropsychiatric conditions.
      Title: Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes.
    5. Npas1-expressing neurons and parvalbumin-expressing neurons are two distinct functional classes of globus pallidus neurons.
      Title: Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus.
    6. The result of this study provided the evidence that NPAS1 represses the generation of specific subtypes of cortical interneurons.
      Title: NPAS1 represses the generation of specific subtypes of cortical interneurons.
    7. These results suggest that NPAS1 plays a novel and important role in regulating TH level of dopaminergic neurons in the ventral midbrain during development.
      Title: Neuronal PAS domain protein 1 regulates tyrosine hydroxylase level in dopaminergic neurons.
    8. a regulatory program controlled in inhibitory interneurons by the NPAS1 and NPAS3 transcription factors may be either substantively or tangentially relevant to psychosis
      Title: Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors.
    9. Npas1 can regulate myofibroblast distribution, branching morphogenesis, and neuroendocrine cell differentiation in murine embryonic lung.
      Title: NPAS1 regulates branching morphogenesis in embryonic lung.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within maternal behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within startle response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronal PAS domain-containing protein 1
    Names
    neuronal PAS1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417027.1 → NP_001403956.1  neuronal PAS domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164880

    2. NM_008718.2 → NP_032744.1  neuronal PAS domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_032744.1

      Status: VALIDATED

      Source sequence(s)
      AC164880, BC137863, BY279348
      Consensus CDS
      CCDS20850.1
      UniProtKB/Swiss-Prot
      P97459
      UniProtKB/TrEMBL
      A2RSH6
      Related
      ENSMUSP00000002053.9, ENSMUST00000002053.9
      Conserved Domains (3) summary
      smart00091
      Location:141 → 198
      PAS; PAS domain
      pfam08447
      Location:316 → 387
      PAS_3; PAS fold
      cd19731
      Location:43 → 116
      bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16189643..16210741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152765.1 → XP_036008658.1  neuronal PAS domain-containing protein 1 isoform X3

      Conserved Domains (2) summary
      smart00091
      Location:141 → 198
      PAS; PAS domain
      cd19731
      Location:43 → 116
      bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

    2. XM_017322022.3 → XP_017177511.1  neuronal PAS domain-containing protein 1 isoform X4

      Conserved Domains (2) summary
      smart00091
      Location:141 → 198
      PAS; PAS domain
      cd19731
      Location:43 → 116
      bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins

    3. XM_017322021.3 → XP_017177510.1  neuronal PAS domain-containing protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P97459
      UniProtKB/TrEMBL
      A2RSH6
      Related
      ENSMUSP00000147412.2, ENSMUST00000210748.2
      Conserved Domains (3) summary
      smart00091
      Location:141 → 198
      PAS; PAS domain
      pfam08447
      Location:316 → 387
      PAS_3; PAS fold
      cd19731
      Location:43 → 116
      bHLH-PAS_NPAS1_PASD5; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 1 (NPAS1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97459.1 GenPept UniProtKB/Swiss-Prot:P97459

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