Dlg1 discs large MAGUK scaffold protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dlg1provided by MGI
Official Full Name: discs large MAGUK scaffold protein 1provided by MGI
Primary source: MGI:MGI:107231
See related: Ensembl:ENSMUSG00000022770 AllianceGenome:MGI:107231
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dlgh1; SAP97; SAP-97; mKIAA4187; E-dlg/SAP97; B130052P05Rik
Summary: Enables molecular adaptor activity and potassium channel regulator activity. A structural constituent of postsynaptic density. Involved in several processes, including membrane repolarization during ventricular cardiac muscle cell action potential; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of potassium ion transmembrane transport. Acts upstream of or within several processes, including hard palate development; negative regulation of cell population proliferation; and negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including basolateral plasma membrane; immunological synapse; and lateral loop. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and surface ectoderm. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human DLG1 (discs large MAGUK scaffold protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cortex adult (RPKM 13.3), bladder adult (RPKM 13.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B2; 16 22.4 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (31482261..31692174)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (31663443..31873356)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Involvement of SAP97 anchored multiprotein complexes in regulating cardiorenal signaling and trafficking networks.
Title: Involvement of SAP97 anchored multiprotein complexes in regulating cardiorenal signaling and trafficking networks.
GRK5 Controls SAP97-Dependent Cardiotoxic beta1 Adrenergic Receptor-CaMKII Signaling in Heart Failure.
Title: GRK5 Controls SAP97-Dependent Cardiotoxic β(1) Adrenergic Receptor-CaMKII Signaling in Heart Failure.
LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
Title: LGI1-ADAM22-MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention.
DLG1 joins a growing list of genes encoding ion channel interacting proteins (ChIPs) identified as potential channelopathy-susceptibility genes because of their ability to regulate the trafficking, targeting, and modulation of ion channels that are critical for the generation and propagation of the cardiac electrical impulse.
Title: Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk.
The results reveal an unexpected function of Dlg1 in restraining hyper-antibody responses through the inhibition of FoxO1 and thus antigen-binding-induced proliferation in B cells.
Title: Discs large homolog 1 regulates B-cell proliferation and antibody production.
The carboxyl-terminal region of KIF13B containing the CAP-Gly domain is important for the LRP1-DLG1-KIF13B complex formation with implications in the regulation of metabolism, cell polarity, and development.
Title: LDL receptor related protein 1 requires the I(3) domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B.
this study shows that Dlg1 maintains dendritic cell function by securing voltage-gated K(+) channel integrity
Title: Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K(+) Channel Integrity.
In vivo analysis of the Dlg1-deficient intestine revealed improper orientation of mitotic spindles and a decreased rate of cellular migration. Loss of Dlg1 decreased survival in Apc(+/min) mice, validating its role as a tumor suppressor in the intestine.
Title: Epigenetic Regulation of Dlg1, via Kaiso, Alters Mitotic Spindle Polarity and Promotes Intestinal Tumorigenesis.
Subjecting SAP97-cKO mice to a battery of behavioral tests revealed a subtle male-specific cognitive deficit and female-specific motor deficit, while other behaviors were largely unaffected. These data suggest that loss of SAP97 may have a modest contribution to organismal behavior.
Title: SAP97 regulates behavior and expression of schizophrenia risk enriched gene sets in mouse hippocampus.
we found that Dlg1 was expressed at different stages of oocyte development. at the germinal vesicle stage, Dlg1 was present in the cytoplasm, prominently surrounding the germinal vesicle membrane. During maturation, Dlg1 became highly polarised by associating with the spindle and formed characteristic crescent-shaped accumulations under the cortex.
Title: Discs large homologue 1 (Dlg1) coordinates mouse oocyte polarisation during maturation.

Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2) 1 citation
Targeted (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

38.MMHAP79FRE11.seq (e-PCR)
- UniSTS:124297

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L27 domain binding	IEA Inferred from Electronic Annotation more info
enables L27 domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables ionotropic glutamate receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	ISO Inferred from Sequence Orthology more info	PubMed
enables kinesin binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	ISS Inferred from Sequence or Structural Similarity more info
enables potassium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables potassium channel regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within amyloid precursor protein metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in astral microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	IEA Inferred from Electronic Annotation more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to brain-derived neurotrophic factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in cortical actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cortical actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cortical microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in cortical microtubule organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial structure maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of centrosome localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of centrosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hard palate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunological synapse formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane raft organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membrane repolarization during ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IEP Inferred from Expression Pattern more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peristalsis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of developmental growth	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of multicellular organism growth	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor localization to synapse	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion export across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of potassium ion import	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to synapse	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization to synapse	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within reproductive structure development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smooth muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of MPP7-DLG1-LIN7 complex	IEA Inferred from Electronic Annotation more info
part_of MPP7-DLG1-LIN7 complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in adherens junction	TAS Traceable Author Statement more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in basal plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell projection membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in lateral loop	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in myelin sheath abaxonal region	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: disks large homolog 1

Names: discs, large homolog 1; embryo-dlg/synapse-associated protein 97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252433.1 → NP_001239362.1 disks large homolog 1 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC129214, AY159380, BU058018

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (8) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00072
Location:713 → 880

GuKc; Guanylate kinase homologues

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:702 → 880

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001252434.1 → NP_001239363.1 disks large homolog 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC129214, AK143780, AY159380, BU058018

Consensus CDS

CCDS57026.1

UniProtKB/TrEMBL

H7BWY4, Q3UP61

Related

ENSMUSP00000023454.6, ENSMUST00000023454.12

Conserved Domains (8) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00072
Location:692 → 859

GuKc; Guanylate kinase homologues

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:681 → 859

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001252435.1 → NP_001239364.1 disks large homolog 1 isoform 4

See identical proteins and their annotated locations for NP_001239364.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC126055, AC129214

Consensus CDS

CCDS57025.1

UniProtKB/Swiss-Prot

Q62402, Q6PGB5, Q811D0, Q8CGN7

UniProtKB/TrEMBL

Q3UP61

Related

ENSMUSP00000110859.2, ENSMUST00000115205.9

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:714 → 892

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001252436.1 → NP_001239365.1 disks large homolog 1 isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (5) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC129214, AK142893, CF164686

Consensus CDS

CCDS57027.1

UniProtKB/TrEMBL

D3Z3B8, Q3UP61

Related

ENSMUSP00000110850.2, ENSMUST00000115196.8

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00072
Location:654 → 821

GuKc; Guanylate kinase homologues

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:643 → 821

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:107 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001357281.1 → NP_001344210.1 disks large homolog 1 isoform 7

Status: VALIDATED

Source sequence(s)

AC126055, AC129214

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:453 → 519

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:334 → 418

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:95 → 179

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:592 → 770

Guanylate_kin; Guanylate kinase

pfam10600
Location:275 → 336

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 94

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_001357282.1 → NP_001344211.1 disks large homolog 1 isoform 8

Status: VALIDATED

Source sequence(s)

AC126055, AC129214

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:688 → 866

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
NM_007862.3 → NP_031888.2 disks large homolog 1 isoform 1

See identical proteins and their annotated locations for NP_031888.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC129214, BC057118, BU058018

Consensus CDS

CCDS28107.1

UniProtKB/TrEMBL

Q3UP61

Related

ENSMUSP00000064280.8, ENSMUST00000064477.14

Conserved Domains (8) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00072
Location:747 → 914

GuKc; Guanylate kinase homologues

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:736 → 914

Guanylate_kin; Guanylate kinase

pfam09058
Location:4 → 62

L27_1; L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

RNA

NR_045516.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) lacks two exons, includes an alternate exon, and uses an alternate internal splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC129214, AK220189, BU058018

Related

ENSMUST00000132176.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

31482261..31692174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521761.4 → XP_006521824.1 disks large homolog 1 isoform X1

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:748 → 926

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521763.4 → XP_006521826.1 disks large homolog 1 isoform X3

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:743 → 921

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521762.4 → XP_006521825.1 disks large homolog 1 isoform X2

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:747 → 925

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017316865.2 → XP_017172354.1 disks large homolog 1 isoform X4

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:735 → 913

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521765.4 → XP_006521828.1 disks large homolog 1 isoform X6

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:726 → 904

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521766.4 → XP_006521829.1 disks large homolog 1 isoform X8

UniProtKB/TrEMBL

E9Q9H0, Q3UP61

Related

ENSMUSP00000110855.2, ENSMUST00000115201.8

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:721 → 899

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521768.4 → XP_006521831.1 disks large homolog 1 isoform X10

See identical proteins and their annotated locations for XP_006521831.1

UniProtKB/Swiss-Prot

Q62402, Q6PGB5, Q811D0, Q8CGN7

UniProtKB/TrEMBL

Q3UP61

Related

ENSMUSP00000097581.4, ENSMUST00000100001.10

Conserved Domains (7) summary

cd12031
Location:582 → 648

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:463 → 547

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:714 → 892

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:404 → 465

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521764.5 → XP_006521827.1 disks large homolog 1 isoform X5

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:567 → 633

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:448 → 532

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:733 → 911

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:406 → 450

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_036159767.1 → XP_036015660.1 disks large homolog 1 isoform X7

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:567 → 633

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:448 → 532

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:224 → 308

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:721 → 899

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:406 → 450

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 223

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521767.5 → XP_006521830.1 disks large homolog 1 isoform X9

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:715 → 893

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_030248959.2 → XP_030104819.1 disks large homolog 1 isoform X11

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:703 → 881

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_030248960.2 → XP_030104820.1 disks large homolog 1 isoform X12

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:549 → 615

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:430 → 514

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:693 → 871

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:371 → 432

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017316872.1 → XP_017172361.1 disks large homolog 1 isoform X25

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:534 → 600

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:415 → 499

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:191 → 275

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:700 → 878

Guanylate_kin; Guanylate kinase

pfam09058
Location:2 → 62

L27_1

pfam10600
Location:373 → 417

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:106 → 190

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521770.5 → XP_006521833.1 disks large homolog 1 isoform X14

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:486 → 552

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:367 → 451

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:128 → 212

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:652 → 830

Guanylate_kin; Guanylate kinase

pfam10600
Location:308 → 369

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 127

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_030248962.2 → XP_030104822.1 disks large homolog 1 isoform X18

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:453 → 519

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:334 → 418

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:95 → 179

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:619 → 797

Guanylate_kin; Guanylate kinase

pfam10600
Location:275 → 336

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 94

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017316869.2 → XP_017172358.1 disks large homolog 1 isoform X22

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:453 → 519

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:334 → 418

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:95 → 179

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:597 → 775

Guanylate_kin; Guanylate kinase

pfam10600
Location:275 → 336

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:10 → 94

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521769.4 → XP_006521832.1 disks large homolog 1 isoform X13

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:665 → 843

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:107 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_030248961.2 → XP_030104821.1 disks large homolog 1 isoform X16

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (7) summary

cd12031
Location:499 → 565

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:380 → 464

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:631 → 809

Guanylate_kin; Guanylate kinase

pfam10600
Location:321 → 382

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:107 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_017316867.3 → XP_017172356.1 disks large homolog 1 isoform X17

Conserved Domains (7) summary

cd12031
Location:484 → 550

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:365 → 449

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

COG3087
Location:30 → 130

FtsN; Cell division protein FtsN [Cell cycle control, cell division, chromosome partitioning]

cd00992
Location:141 → 225

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:628 → 806

Guanylate_kin; Guanylate kinase

pfam10600
Location:323 → 367

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:107 → 140

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521771.4 → XP_006521834.1 disks large homolog 1 isoform X15

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:632 → 810

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:78 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521772.4 → XP_006521835.1 disks large homolog 1 isoform X19

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:610 → 788

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:78 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_036159768.1 → XP_036015661.1 disks large homolog 1 isoform X20

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:605 → 783

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_006521773.4 → XP_006521836.1 disks large homolog 1 isoform X21

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:466 → 532

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:347 → 431

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:598 → 776

Guanylate_kin; Guanylate kinase

pfam10600
Location:288 → 349

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:78 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_036159769.1 → XP_036015662.1 disks large homolog 1 isoform X23

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:451 → 517

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:332 → 416

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:595 → 773

Guanylate_kin; Guanylate kinase

pfam10600
Location:290 → 334

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK
XM_036159770.1 → XP_036015663.1 disks large homolog 1 isoform X24

UniProtKB/TrEMBL

Q3UP61

Conserved Domains (6) summary

cd12031
Location:451 → 517

SH3_DLG1; Src Homology 3 domain of Disks Large homolog 1

smart00228
Location:332 → 416

PDZ; Domain present in PSD-95, Dlg, and ZO-1/2

cd00992
Location:108 → 192

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam00625
Location:590 → 768

Guanylate_kin; Guanylate kinase

pfam10600
Location:290 → 334

PDZ_assoc; PDZ-associated domain of NMDA receptors

pfam10608
Location:29 → 107

MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK