Rab23 RAB23, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab23provided by MGI
Official Full Name: RAB23, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:99833
See related: Ensembl:ENSMUSG00000004768 AllianceGenome:MGI:99833
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: opb; opb2; rab-15
Summary: Predicted to enable GTPase activity. Involved in dorsal/ventral neural tube patterning and neural tube closure. Acts upstream of or within several processes, including embryonic digit morphogenesis; regulation of smoothened signaling pathway; and spinal cord dorsal/ventral patterning. Located in endosome membrane and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human RAB23 (RAB23, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 5.6), limb E14.5 (RPKM 5.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 12.8 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (33758991..33781642)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (33719896..33742564)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.
Title: Multifaceted Functions of Rab23 on Primary Cilium-Mediated and Hedgehog Signaling-Mediated Cerebellar Granule Cell Proliferation.
RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.
Title: RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1.
results demonstrate that the Rab23-Kif17-cargo complex regulates tubulin acetylation for spindle organization and drives actin-mediated spindle migration during meiosis.
Title: Rab23/Kif17 regulate meiotic progression in oocytes by modulating tubulin acetylation and actin dynamics.
These studies suggest that cortical neuron migration is mediated by a molecular hierarchy downstream of Rab23 via N-cadherin.
Title: Rab23 Regulates Radial Migration of Projection Neurons via N-cadherin.
Our findings have uncovered a hitherto unknown effector of Rab23 and demonstrate how Rab23 could mediate the transport of Kif17 to the primary cilium
Title: A role for Rab23 in the trafficking of Kif17 to the primary cilium.
D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23.
Title: Dopamine receptors reveal an essential role of IFT-B, KIF17, and Rab23 in delivering specific receptors to primary cilia.
this study showed that Rab23 regulates Nodal signaling in left- right patterning of th emouse and zebrafish.
Title: Rab23 regulates Nodal signaling in vertebrate left-right patterning independently of the Hedgehog pathway.
Rab23 is involved in the control of Sox9 expression via Gli1 protein
Title: Rab23 regulates differentiation of ATDC5 chondroprogenitor cells.
Rab23 regulates subcellular localization of essential components of the Hedgehog pathway that act downstream of Smoothened and upstream of Gli proteins.
Title: Mouse Rab23 regulates hedgehog signaling from smoothened to Gli proteins.
Expression of Rab23 in the adult brain is suggestive, however, of having a postnatal function beyond its role in embryonic development.
Title: Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Gene trapped (1)
Spontaneous (1) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab23 (e-PCR), detects polymorphism
- UniSTS:526924

AW545388 (e-PCR)
- UniSTS:178372

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GTP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in cellular defense response	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in dorsal/ventral neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic digit morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in autophagosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-23

Names: open brain 2; protein open brain

NP_001153201.1

EC 3.6.5.2

NP_001407727.1

EC 3.6.5.2

NP_001407728.1

EC 3.6.5.2

NP_001407729.1

EC 3.6.5.2

NP_033025.2

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.