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    Slc35f6 solute carrier family 35, member F6 [ Mus musculus (house mouse) ]

    Gene ID: 74919, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc35f6provided by MGI
    Official Full Name
    solute carrier family 35, member F6provided by MGI
    Primary source
    MGI:MGI:1922169
    See related
    Ensembl:ENSMUSG00000029175 AllianceGenome:MGI:1922169
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P40; ANT2BP; Tango9; 4930471M23Rik; 5730478O19Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and positive regulation of cell population proliferation. Located in lysosome. Orthologous to human SLC35F6 (solute carrier family 35 member F6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 21.2), adrenal adult (RPKM 19.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc35f6 in Genome Data Viewer
    Location:
    5 B1; 5 16.74 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30805272..30817073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30647939..30659729)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene calcium and integrin binding family member 4 Neighboring gene predicted gene, 40272 Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3 Neighboring gene STARR-seq mESC enhancer starr_12757 Neighboring gene STARR-seq mESC enhancer starr_12759 Neighboring gene microRNA 5625 Neighboring gene STARR-positive B cell enhancer ABC_E4748 Neighboring gene centromere protein A Neighboring gene predicted gene, 57741

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Intracellular localization of p40, a protein identified in a preparation of lysosomal membranes. Boonen M, et al. Biochem J, 2006 Apr 1. PMID 16367739, Free PMC Article
    2. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 35 member F6
    Names
    ANT2-binding protein
    transmembrane protein C2orf18 homolog
    transport and Golgi organization 9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175675.3 → NP_783606.2  solute carrier family 35 member F6 precursor

      See identical proteins and their annotated locations for NP_783606.2

      Status: VALIDATED

      Source sequence(s)
      AK049408, AK051359, BY166812
      Consensus CDS
      CCDS19161.1
      UniProtKB/Swiss-Prot
      Q3UB33, Q8BKN1, Q8VE96, Q9D5B2
      UniProtKB/TrEMBL
      Q8BK02
      Related
      ENSMUSP00000058680.6, ENSMUST00000062962.12
      Conserved Domains (1) summary
      cl23754
      Location:105 → 160
      EamA; EamA-like transporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30805272..30817073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165569.1 → XP_036021462.1  solute carrier family 35 member F6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JEG3
      Related
      ENSMUSP00000142761.2, ENSMUST00000196740.5
      Conserved Domains (1) summary
      pfam04142
      Location:31 → 105
      Nuc_sug_transp; Nucleotide-sugar transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VE96.1 GenPept UniProtKB/Swiss-Prot:Q8VE96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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