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    Cimip2c ciliary microtubule inner protein 2C [ Mus musculus (house mouse) ]

    Gene ID: 75434, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cimip2cprovided by MGI
    Official Full Name
    ciliary microtubule inner protein 2Cprovided by MGI
    Primary source
    MGI:MGI:1922684
    See related
    Ensembl:ENSMUSG00000029182 AllianceGenome:MGI:1922684
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam166c; 1700001C02Rik; 1700047H18Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in central nervous system; femur; lung; and retina. Orthologous to human CIMIP2C (ciliary microtubule inner protein 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 128.9) See more
    Orthologs
    human all
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    Genomic context

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    See Cimip2c in Genome Data Viewer
    Location:
    5 B1; 5 16.57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (30623395..30641433)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30466029..30484089)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:30645501-30645684 Neighboring gene dynein regulatory complex subunit 1 Neighboring gene otoferlin Neighboring gene STARR-seq mESC enhancer starr_12752 Neighboring gene calcium and integrin binding family member 4 Neighboring gene predicted gene, 40272 Neighboring gene predicted gene 9899 Neighboring gene potassium channel, subfamily K, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In-cell structural insight into the stability of sperm microtubule doublet. Tai L, et al. Cell Discov, 2023 Nov 21. PMID 37989994, Free PMC Article
    2. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417
    3. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axonemal microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ciliary microtubule inner protein 2C
    Names
    UPF0573 protein C2orf70 homolog
    family with sequence similarity 166, member C
    protein FAM166C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417888.1 → NP_001404817.1  ciliary microtubule inner protein 2C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157761

    2. NM_001417889.1 → NP_001404818.1  ciliary microtubule inner protein 2C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157761
      UniProtKB/TrEMBL
      D3Z6F6
      Related
      ENSMUSP00000110391.2, ENSMUST00000114743.2

    3. NM_029285.2 → NP_083561.1  ciliary microtubule inner protein 2C isoform 1

      See identical proteins and their annotated locations for NP_083561.1

      Status: VALIDATED

      Source sequence(s)
      AC157761
      Consensus CDS
      CCDS19158.1
      UniProtKB/Swiss-Prot
      Q9D9M8, Q9DAS2
      Related
      ENSMUSP00000031078.4, ENSMUST00000031078.10
      Conserved Domains (1) summary
      pfam10629
      Location:19 → 83
      DUF2475; Protein of unknown function (DUF2475)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      30623395..30641433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240783.2 → XP_011239085.1  ciliary microtubule inner protein 2C isoform X1

      Conserved Domains (1) summary
      pfam10629
      Location:23 → 80
      DUF2475; Protein of unknown function (DUF2475)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAS2.1 GenPept UniProtKB/Swiss-Prot:Q9DAS2

    Gene LinkOut

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