Bcl9 B cell CLL/lymphoma 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcl9provided by MGI
Official Full Name: B cell CLL/lymphoma 9provided by MGI
Primary source: MGI:MGI:1924828
See related: Ensembl:ENSMUSG00000038256 AllianceGenome:MGI:1924828
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm130; 2610202E01Rik; 8030475K17Rik; A330041G23Rik
Summary: Enables beta-catenin binding activity. Acts upstream of or within several processes, including myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription by RNA polymerase II; and skeletal muscle cell differentiation. Located in cis-Golgi network; nucleus; and sarcoplasm. Is expressed in several structures, including brain; eye; head surface ectoderm; metanephros; and thymus primordium. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 13.7), CNS E11.5 (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 42.04 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (97110974..97205718, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (97203658..97298402, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.
Title: Targeting BCL9/BCL9L enhances antigen presentation by promoting conventional type 1 dendritic cell (cDC1) activation and tumor infiltration.
miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9.
Title: miRNA-122-5p in POI ovarian-derived exosomes promotes granulosa cell apoptosis by regulating BCL9.
BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
Title: BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
Title: BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
TBX3 acts as tissue-specific component of the Wnt/beta-catenin transcriptional complex.
Title: TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex.
Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
ARX positively regulates Wnt/ beta-catenin signaling and the C-terminal domain of ARX interacts with the armadillo repeats in beta-catenin to promote Wnt/beta-catenin signaling. In addition, we found BCL9 and P300 also interact with ARX to modulate Wnt/beta-catenin signaling.
Title: Aristaless Related Homeobox (ARX) Interacts with β-Catenin, BCL9, and P300 to Regulate Canonical Wnt Signaling.
Study demonstrates that the Golgi resident protein GM130 activates the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and further captures them to couple mitotic membranes to the spindle.
Title: GM130 Regulates Golgi-Derived Spindle Assembly by Activating TPX2 and Capturing Microtubules.
Pax6, the master regulator of eye development, directly activates Bcl9/9l transcription.
Title: Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development.
These results suggest a critical role of BCL9/9-2 in the Wnt-mediated regulation of adult, as opposed to embryonic, myogenic progenitors.
Title: BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within somatic stem cell population maintenance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
part_of beta-catenin-TCF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of beta-catenin-TCF complex	IEA Inferred from Electronic Annotation more info
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: B-cell CLL/lymphoma 9 protein

Names: B-cell lymphoma 9 protein; bcl-9; nuclear co-factor of beta-catenin signalling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429224.1 → NP_001416153.1 B-cell CLL/lymphoma 9 protein isoform 2

Status: VALIDATED

Source sequence(s)

AC140071

UniProtKB/Swiss-Prot

B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
NM_001429225.1 → NP_001416154.1 B-cell CLL/lymphoma 9 protein isoform 1

Status: VALIDATED

Source sequence(s)

AC140071
NM_001429226.1 → NP_001416155.1 B-cell CLL/lymphoma 9 protein isoform 1

Status: VALIDATED

Source sequence(s)

AC140071
NM_001429227.1 → NP_001416156.1 B-cell CLL/lymphoma 9 protein isoform 2

Status: VALIDATED

Source sequence(s)

AC140071

UniProtKB/Swiss-Prot

B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219
NM_029933.5 → NP_084209.3 B-cell CLL/lymphoma 9 protein isoform 1

See identical proteins and their annotated locations for NP_084209.3

Status: VALIDATED

Source sequence(s)

AC140071

Consensus CDS

CCDS17654.1

UniProtKB/Swiss-Prot

B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219

Related

ENSMUSP00000046152.8, ENSMUST00000046521.14

Conserved Domains (2) summary

PHA03247
Location:570 → 1160

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:350 → 388

BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

97110974..97205718 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502288.4 → XP_006502351.1 B-cell CLL/lymphoma 9 protein isoform X1

Conserved Domains (2) summary

PHA03247
Location:570 → 1160

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:350 → 388

BCL9; B-cell lymphoma 9 protein
XM_030252892.2 → XP_030108752.1 B-cell CLL/lymphoma 9 protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:496 → 1086

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:276 → 314

BCL9; B-cell lymphoma 9 protein
XM_006502290.4 → XP_006502353.1 B-cell CLL/lymphoma 9 protein isoform X1

See identical proteins and their annotated locations for XP_006502353.1

UniProtKB/Swiss-Prot

B2RQC0, Q67FX9, Q8BUJ8, Q8VE74, Q9D219

Conserved Domains (2) summary

PHA03247
Location:570 → 1160

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:350 → 388

BCL9; B-cell lymphoma 9 protein
XM_036163404.1 → XP_036019297.1 B-cell CLL/lymphoma 9 protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:496 → 1086

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:276 → 314

BCL9; B-cell lymphoma 9 protein
XM_006502292.5 → XP_006502355.1 B-cell CLL/lymphoma 9 protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:496 → 1086

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:276 → 314

BCL9; B-cell lymphoma 9 protein
XM_006502289.5 → XP_006502352.1 B-cell CLL/lymphoma 9 protein isoform X1

Related

ENSMUSP00000131692.2, ENSMUST00000166341.2

Conserved Domains (2) summary

PHA03247
Location:570 → 1160

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:350 → 388

BCL9; B-cell lymphoma 9 protein
XM_030252891.1 → XP_030108751.1 B-cell CLL/lymphoma 9 protein isoform X2

Conserved Domains (2) summary

PHA03247
Location:570 → 1148

PHA03247; large tegument protein UL36; Provisional

pfam11502
Location:350 → 388

BCL9; B-cell lymphoma 9 protein