ERD5 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ERD5
Official Full Name: Methylenetetrahydrofolate reductase family protein
Primary source: TAIR:AT3G30775
Locus tag: AT3G30775
See related: Araport:AT3G30775
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PROLINE OXIDASE; AT-POX; ATPDH; ATPOX; EARLY RESPONSIVE TO DEHYDRATION 5; PDH1; PRO1; PRODH; PROLINE DEHYDROGENASE; proline dehydrogenase 1; PROLINE OXIDASE
Summary: Encodes a proline oxidase that is predicted to localize to the inner mitochondrial membrane, its mRNA expression induced by high levels of Al and by osmotic stress. The promoter contains an L-proline-inducible element.
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Genomic context

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See ERD5 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 5

Sequence:: Chromosome: 3; NC_003074.8 (12448636..12451556, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ProDH1 and ProDH2 are both necessary to achieve maximum resistance against Pseudomonas syringae pv. tomato AvrRpm1 and B. cinerea.[ProDH1]
Title: Differential control and function of Arabidopsis ProDH1 and ProDH2 genes on infection with biotrophic and necrotrophic pathogens.
ARR18 interaction negatively interferes with the transcriptional activity of bZIP63 on the PDH1 promoter. [PDH1]
Title: The interaction of the Arabidopsis response regulator ARR18 with bZIP63 mediates the regulation of PROLINE DEHYDROGENASE expression.
ProDH potentiates the oxidative burst and cell death associated with the hypersensitive response.
Title: Proline dehydrogenase is a positive regulator of cell death in different kingdoms.
ProDH-silenced plants displayed reduced ROS and cell death levels as well as enhanced susceptibility in response to avirulent pathogens.
Title: Proline dehydrogenase contributes to pathogen defense in Arabidopsis.
bZIP11 target processes are identified using transiently increased nuclear bZIP11 levels and genome-wide expression analysis; the effect of bZIP11 on ASN1 and GBF6 are reported.
Title: The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE SYNTHETASE1 and PROLINE DEHYDROGENASE2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001339059.1

Supported by ESTs:

NM_113981.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables proline dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables proline dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within proline catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Methylenetetrahydrofolate reductase family protein

NP_001319672.1

EARLY RESPONSIVE TO DEHYDRATION 5 (ERD5); CONTAINS InterPro DOMAIN/s: Proline dehydrogenase (InterPro:IPR002872), Proline oxidase (InterPro:IPR015659); BEST Arabidopsis thaliana protein match is: Methylenetetrahydrofolate reductase family protein (TAIR:AT5G38710.1); Has 2269 Blast hits to 2250 proteins in 878 species: Archae - 1; Bacteria - 1355; Metazoa - 205; Fungi - 217; Plants - 85; Viruses - 2; Other Eukaryotes - 404 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

12448636..12451556 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001339059.1 → NP_001319672.1 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

P92945, P92983, Q8VXV1, Q944L2, Q96281

UniProtKB/TrEMBL

A0A7G2EQV6
NM_113981.6 → NP_189701.3 Methylenetetrahydrofolate reductase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

P92945, P92983, Q8VXV1, Q944L2, Q96281

UniProtKB/TrEMBL

A0A7G2EQV6

Conserved Domains (2) summary

PLN02681
Location:40 → 499

PLN02681; proline dehydrogenase

pfam01619
Location:169 → 475

Pro_dh; Proline dehydrogenase