Fam111a FAM111 trypsin like peptidase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fam111aprovided by RGD
Official Full Name: FAM111 trypsin like peptidase Aprovided by RGD
Primary source: RGD:1560913
See related: EnsemblRapid:ENSRNOG00000012067 AllianceGenome:RGD:1560913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1560913
Summary: Predicted to enable single-stranded DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of viral genome replication; and protein autoprocessing. Predicted to be located in chromatin; cytoplasm; and nuclear lumen. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Kenny-Caffey syndrome type 2. Orthologous to human FAM111A (FAM111 trypsin like peptidase A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 183.3), Spleen (RPKM 129.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (219065542..219081213)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (209640865..209656551)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (229003778..229019532)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142585 (e-PCR)
- UniSTS:231832

RH143407 (e-PCR)
- UniSTS:232654

RH128361 (e-PCR)
- UniSTS:211669

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables single-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA replication	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA covalent cross-linking repair	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in replication fork processing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FAM111 trypsin like peptidase A

Names: family with sequence similarity 111, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109163.1 → NP_001102633.1 FAM111 trypsin like peptidase A

See identical proteins and their annotated locations for NP_001102633.1

Status: PROVISIONAL

Source sequence(s)

CH473953

UniProtKB/TrEMBL

A6I0E1, D4A8N0

Related

ENSRNOP00000016152.5, ENSRNOT00000016152.8

Conserved Domains (2) summary

pfam13365
Location:367 → 556

Trypsin_2; Trypsin-like peptidase domain

cl21584
Location:529 → 588

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

219065542..219081213

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087912.2 → XP_038943840.1 FAM111 trypsin like peptidase A isoform X1

UniProtKB/TrEMBL

A6I0E1, D4A8N0

Conserved Domains (2) summary

pfam13365
Location:367 → 556

Trypsin_2; Trypsin-like peptidase domain

cl21584
Location:529 → 588

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_039087916.2 → XP_038943844.1 FAM111 trypsin like peptidase A isoform X1

UniProtKB/TrEMBL

A6I0E1, D4A8N0

Conserved Domains (2) summary

pfam13365
Location:367 → 556

Trypsin_2; Trypsin-like peptidase domain

cl21584
Location:529 → 588

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...