Reg3a regenerating islet-derived 3 alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Reg3aprovided by RGD
Official Full Name: regenerating islet-derived 3 alphaprovided by RGD
Primary source: RGD:621401
See related: EnsemblRapid:ENSRNOG00000006360 AllianceGenome:RGD:621401
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pap2; PapII
Summary: Predicted to enable oligosaccharide binding activity; peptidoglycan binding activity; and signaling receptor activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of keratinocyte differentiation; and positive regulation of keratinocyte proliferation. Predicted to be active in extracellular space. Used to study acute pancreatitis. Orthologous to human REG3A (regenerating family member 3 alpha) and REG3G (regenerating family member 3 gamma). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 34.1), Liver (RPKM 18.2) and 1 other tissue See more
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Genomic context

Location:: 4q33

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (112430397..112433163)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (110872398..110875157)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (109477893..109480659)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The pancreas reacts to remote lesions and septic insults in mice and rats with increased PSP synthesis, while PAP is selectively responsive to septic events. Furthermore, our results suggest that serum PSP in septic patients is predominantly derived through an acute phase response of the pancreas.
Title: The pancreas responds to remote damage and systemic stress by secretion of the pancreatic secretory proteins PSP/regI and PAP/regIII.
Alox15 mRNA levels were 4 times higher in iron-deficient than in iron-adequate pancreas and that Reg1a, Reg3a, and Reg3b mRNA levels were 17-36 times higher in iron-overloaded pancreas.
Title: Microarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.
Findings suggest that islet neogenesis-associated protein (INGAP) exerts a positive modulatory effect on beta-cell mass and its secretory function in fetal and neonatal rats, thus becoming a new component in the multifactorial regulation of such processes.
Title: Islet neogenesis-associated protein (INGAP)-positive cell mass, β-cell mass, and insulin secretion: their relationship during the fetal and neonatal periods.
After duodenal-jejunal bypass, the level of Reg3alpha and -3beta were not changed in bypassed duodenum in morbidly obese Zucker fatty rats.
Title: Intestinal adaptation and Reg gene expression induced by antidiabetic duodenal-jejunal bypass surgery in Zucker fatty rats.
Letter: aggregation status of PAP1 and PAP2 could change their role in regulating the inflammation in acute pancreatitis.
Title: Pancreatitis-associated proteins' regulation of inflammation is correlated with their ability to aggregate.
preincubation with select rPAP2 mutant proteins affect translocation of this transcription factor into the nucleus
Title: Mutational characterization of pancreatitis-associated protein 2 domains involved in mediating cytokine secretion in macrophages and the NF-kappaB pathway.
Pancreatitis-associated protein 2 stimulates macrophage activity and likely modulates the inflammatory environment of pancreatitis
Title: Pancreatitis-associated protein 2 modulates inflammatory responses in macrophages.
There is a tight spatial and temporal association between pre-inflammatory changes or inflammation and PAP-expression.
Title: Coordinate regulation of PSP/reg and PAP isoforms as a family of secretory stress proteins in an animal model of chronic pancreatitis.
Small interfering RNA-mediated gene knockdown of PAP worsens pancreatitis. Differences in gene knockdown technology may provide different approaches to study gene function.
Title: Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptidoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of keratinocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of keratinocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of wound healing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of wound healing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of wound healing	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regenerating islet-derived protein 3-alpha

Names: REG 3; REG-3-alpha; islet of Langerhans regenerating protein 3; lithostathine 3; pancreatitis-associated protein 2; reg III-alpha; regIII; regenerating islet-derived protein III-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145846.2 → NP_001139318.1 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_001139318.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AW532201, CF249035, JAXUCZ010000004, L10229

UniProtKB/Swiss-Prot

P35231

UniProtKB/TrEMBL

A0A0G2JSI6, A6IAG1

Conserved Domains (1) summary

cl02432
Location:39 → 172

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_172077.2 → NP_742074.2 regenerating islet-derived protein 3-alpha precursor

See identical proteins and their annotated locations for NP_742074.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AW532201, CF249035, L10229

UniProtKB/Swiss-Prot

P35231

UniProtKB/TrEMBL

A0A0G2JSI6, A6IAG1

Related

ENSRNOP00000008468.3, ENSRNOT00000008468.7

Conserved Domains (1) summary

cl02432
Location:39 → 172

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain