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    mexB multidrug resistance protein MexB [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877852, updated on 24-Aug-2024

    Summary

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    Gene symbol
    mexB
    Gene description
    multidrug resistance protein MexB
    Locus tag
    PA0426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (473191..476331)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene multidrug resistance operon repressor MexR Neighboring gene multidrug resistance protein MexA Neighboring gene outer membrane protein OprM Neighboring gene ATP-dependent RNA helicase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa. Terzi HA, et al. World J Microbiol Biotechnol, 2014 Oct. PMID 24964907
    2. Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets. Ohene-Agyei T, et al. FEMS Microbiol Lett, 2012 Aug. PMID 22568688
    3. Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa. Sennhauser G, et al. J Mol Biol, 2009 May 29. PMID 19361527
    4. MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa. Ma M, et al. Int J Mol Sci, 2021 May 18. PMID 34070225, Free PMC Article
    5. Roles of MexXY- and MexAB-multidrug efflux pumps in intrinsic multidrug resistance of Pseudomonas aeruginosa PAO1. Morita Y, et al. J Gen Appl Microbiol, 2001 Feb. PMID 12483565

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa.
      Title: MexAB-OprM Efflux Pump Interaction with the Peptidoglycan of Escherichia coli and Pseudomonas aeruginosa.
    2. MexR termination has a role in overexpression of MexAB-OprM efflux pump in Pseudomonas aeruginosa
      Title: Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India.
    3. Efflux pump MexAB-OprM plays an important role in antibiotic resistance in P. aeruginosa, because of acting the efflux pumps on antibiotics in a non-specific manner
      Title: Expression of efflux pump MexAB-OprM and OprD of Pseudomonas aeruginosa strains isolated from clinical samples using qRT-PCR.
    4. Results show that increased transcription of mexB was directly correlated with meropenem resistance in in Pseudomonas aeruginosa.
      Title: The effects of active efflux pumps on antibiotic resistance in Pseudomonas aeruginosa.
    5. The results demonstrate a new quorum sensing regulation mechanism via the efflux system MexAB-OprM in Pseudomonas aeruginosa.
      Title: RND type efflux pump system MexAB-OprM of Pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication.
    6. The FAFA mutation in MexB has a reduced ability to confer resistance to antibiotics with intracellular targets.
      Title: Mutations in MexB that affect the efflux of antibiotics with cytoplasmic targets.
    7. Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon involves repressors NalC and MexR and the antirepressor ArmR
      Title: Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon: involvement of repressors NalC and MexR and the antirepressor ArmR.
    8. Chlorinated phenols control the expression of the MexA, MexB and OprM by interacting with NalC.
      Title: Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC.
    9. MexB acts independently of its cognitive partners, MexA and OprM.
      Title: Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa.
    10. The crystal structure of the Pseudomonas aeruginosa multidrug exporter MexB, is reported.
      Title: Crystal structure of the multidrug exporter MexB from Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    General gene information

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    Homology

    General protein information

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    Preferred Names
    multidrug resistance protein MexB
    NP_249117.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      473191..476331
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249117.1 multidrug resistance protein MexB [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249117.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367MC57
      Conserved Domains (1) summary
      TIGR00915
      Location:1 → 1044
      2A0602; The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52002.2

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