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    gacA response regulator GacA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 880582, updated on 11-Sep-2024

    Summary

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    Gene symbol
    gacA
    Gene description
    response regulator GacA
    Locus tag
    PA2586
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2925788..2926432, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Neighboring gene excinuclease ABC subunit C Neighboring gene 2-heptyl-3-hydroxy-4(1H)-quinolone synthase Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pseudomonas aeruginosa GacA, a factor in multihost virulence, is also essential for biofilm formation. Parkins MD, et al. Mol Microbiol, 2001 Jun. PMID 11401724
    2. Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori. Chieda Y, et al. FEMS Microbiol Lett, 2005 Mar 1. PMID 15727838
    3. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000. O'Malley MR, et al. Mol Plant Pathol, 2020 Jan. PMID 31588661, Free PMC Article
    4. Common virulence factors for bacterial pathogenicity in plants and animals. Rahme LG, et al. Science, 1995 Jun 30. PMID 7604262
    5. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs. Brencic A, et al. Mol Microbiol, 2009 Aug. PMID 19602144, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
      Title: A revised model for the role of GacS/GacA in regulating type III secretion by Pseudomonas syringae pv. tomato DC3000.
    2. LadS HK thus forms, with the GacS/GacA TCS, a multicomponent signal transduction system with an original phosphorelay cascade, i.e. H1LadS-->D1LadS-->H2GacS-->D2GacA.
      Title: The Hybrid Histidine Kinase LadS Forms a Multicomponent Signal Transduction System with the GacS/GacA Two-Component System in Pseudomonas aeruginosa.
    3. GacA regulates rsmY and rsmZ by directly binding to sequences upstream of these genes.
      Title: The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.
    4. A gacA mutant was less virulent to Bombyx mori larvae than the parent strain.
      Title: Pathogenicity of gacA mutant of Pseudomonas aeruginosa PA01 in the silkworm, Bombyx mori.
    5. GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ
      Title: Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.
    6. GacA response regulator negatively affects the T3SS.
      Title: Cross talk between type III secretion and flagellar assembly systems in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    response regulator GacA
    NP_251276.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2925788..2926432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251276.1 response regulator GacA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251276.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5EXS4
      Conserved Domains (1) summary
      PRK09483
      Location:1 → 214
      PRK09483; response regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q51373.2

    Gene LinkOut

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