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    Impact impact, RWD domain protein [ Mus musculus (house mouse) ]

    Gene ID: 16210, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Impactprovided by MGI
    Official Full Name
    impact, RWD domain proteinprovided by MGI
    Primary source
    MGI:MGI:1098233
    See related
    Ensembl:ENSMUSG00000024423 AllianceGenome:MGI:1098233
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E430016J11Rik
    Summary
    Enables actin binding activity; protein sequestering activity; and ribosome binding activity. Involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Acts upstream of or within negative regulation of protein phosphorylation and regulation of translational initiation. Located in cytoplasm. Is expressed in several structures, including brain; extraembryonic component; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 16.8), cerebellum adult (RPKM 14.5) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Impact in Genome Data Viewer
    Location:
    18 A1; 18 6.87 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (13087747..13126007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (12954690..12992950)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:12966807-12966996 Neighboring gene predicted gene, 36439 Neighboring gene STARR-seq mESC enhancer starr_43844 Neighboring gene STARR-seq mESC enhancer starr_43846 Neighboring gene STARR-seq mESC enhancer starr_43847 Neighboring gene ribosomal protein S8 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9448 Neighboring gene histamine receptor H4 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human homolog of the mouse imprinted gene Impact resides at the pericentric region of chromosome 18 within the critical region for bipolar affective disorder. Kosaki K, et al. Mol Psychiatry, 2001 Jan. PMID 11244491
    2. Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Okamura K, et al. Genome Res, 2000 Dec. PMID 11116084
    3. The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control. Pereira CM, et al. PLoS One, 2019. PMID 31166980, Free PMC Article
    4. An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors. Okamura K, et al. DNA Res, 2004 Dec 31. PMID 15871461
    5. Screening for imprinted genes by allelic message display: identification of a paternally expressed gene impact on mouse chromosome 18. Hagiwara Y, et al. Proc Natl Acad Sci U S A, 1997 Aug 19. PMID 9256468, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results indicate that IMPACT contributes to GCN2-dependent and -independent mechanisms involved in the regulation of autonomic functions in response to energy availability.
      Title: The GCN2 inhibitor IMPACT contributes to diet-induced obesity and body temperature control.
    2. This study extends our understanding of the roles played by GCN1 in GCN2 activation induced by a variety of stress arrangements and suggests that IMPACT and YIH1 use similar mechanisms for regulating this eIF2alpha kinase.
      Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
    3. the participation of the GCN2-IMPACT module of translational regulation in a highly controlled step in the development of the nervous system.
      Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth.
    4. segmental duplication followed by enhancement of the promoter activity is responsible for the species-specific imprinting of Impact
      Title: An evolutionary scenario for genomic imprinting of Impact lying between nonimprinted neighbors.
    5. IMPACT ensures constant high levels of translation and low levels of CREB-2 and GADD53 in specific neuronal cells under amino acid starvation conditions.
      Title: IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein sequestering activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GCN2-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection extension IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoplasmic translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    protein IMPACT
    Names
    imprinted and ancient gene protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357396.1 → NP_001344325.1  protein IMPACT isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131672, BM899561
      Conserved Domains (2) summary
      smart00591
      Location:1 → 97
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:164 → 270
      UPF0029; Uncharacterized protein family UPF0029

    2. NM_008378.3 → NP_032404.1  protein IMPACT isoform 1

      See identical proteins and their annotated locations for NP_032404.1

      Status: VALIDATED

      Source sequence(s)
      AC131672, AK138136, BM899561, CJ056911
      Consensus CDS
      CCDS29068.1
      UniProtKB/Swiss-Prot
      O55091, Q3UUR6, Q9EQH0
      Related
      ENSMUSP00000025290.6, ENSMUST00000025290.7
      Conserved Domains (2) summary
      smart00591
      Location:15 → 115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:181 → 288
      UPF0029; Uncharacterized protein family UPF0029

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      13087747..13126007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246850.3 → XP_011245152.1  protein IMPACT isoform X1

      See identical proteins and their annotated locations for XP_011245152.1

      Conserved Domains (2) summary
      smart00591
      Location:1 → 97
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:164 → 270
      UPF0029; Uncharacterized protein family UPF0029

    RNA

    1. XR_001782344.3 RNA Sequence

    2. XR_004939837.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O55091.2 GenPept UniProtKB/Swiss-Prot:O55091

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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