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    Cyb5rl cytochrome b5 reductase-like [ Mus musculus (house mouse) ]

    Gene ID: 230582, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cyb5rlprovided by MGI
    Official Full Name
    cytochrome b5 reductase-likeprovided by MGI
    Primary source
    MGI:MGI:1919657
    See related
    Ensembl:ENSMUSG00000028621 AllianceGenome:MGI:1919657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810410C14Rik
    Summary
    Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in nucleoplasm. Is expressed in cranial ganglion; dorsal root ganglion; and trigeminal nerve. Orthologous to human CYB5RL (cytochrome b5 reductase like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 3.0), kidney adult (RPKM 2.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cyb5rl in Genome Data Viewer
    Location:
    4 C7; 4 49.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106924035..106945204)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107066830..107088007)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6196 Neighboring gene predicted gene, 52672 Neighboring gene single-stranded DNA binding protein 3 Neighboring gene STARR-seq mESC enhancer starr_11016 Neighboring gene STARR-seq mESC enhancer starr_11017 Neighboring gene STARR-positive B cell enhancer ABC_E3500 Neighboring gene VISTA enhancer mm1261 Neighboring gene STARR-positive B cell enhancer ABC_E1035 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene CUB domain containing protein 2 Neighboring gene predicted gene 12802 Neighboring gene transcription elongation factor A (SII) N-terminal and central domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Clone Names

    • FLJ00377

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NADH-cytochrome b5 reductase-like
    NP_001333481.1
    NP_001364012.1
    NP_001364013.1
    NP_001364014.1
    NP_001364015.1
    NP_001364016.1
    NP_001364017.1
    NP_780680.1
    XP_006503009.1
    XP_006503010.1
    XP_006503011.1
    XP_006503013.1
    XP_006503014.1
    XP_006503015.1
    XP_006503017.1
    XP_006503018.1
    XP_006503020.1
    XP_006503022.1
    XP_006503025.1
    XP_011238784.1
    XP_011238786.1
    XP_017175622.1
    XP_030109289.1
    XP_036019906.1
    XP_036019907.1
    XP_036019908.1
    XP_036019909.1
    XP_036019910.1
    XP_036019911.1
    XP_036019912.1
    XP_036019913.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346552.2NP_001333481.1  NADH-cytochrome b5 reductase-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      AL607132
      Consensus CDS
      CCDS84765.1
      UniProtKB/Swiss-Prot
      B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
      Related
      ENSMUSP00000102369.2, ENSMUST00000106758.8
      Conserved Domains (2) summary
      cd06183
      Location:83316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    2. NM_001377083.1NP_001364012.1  NADH-cytochrome b5 reductase-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 4, encodes isoform 1.
      Source sequence(s)
      AL607132
      UniProtKB/Swiss-Prot
      B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
      Conserved Domains (2) summary
      cd06183
      Location:83316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    3. NM_001377084.1NP_001364013.1  NADH-cytochrome b5 reductase-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 1 and 3, encodes isoform 1.
      Source sequence(s)
      AL607132
      UniProtKB/Swiss-Prot
      B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
      Conserved Domains (2) summary
      cd06183
      Location:83316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    4. NM_001377085.1NP_001364014.1  NADH-cytochrome b5 reductase-like isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variant 6, encodes isoform 3.
      Source sequence(s)
      AL607132
      Conserved Domains (2) summary
      cd06183
      Location:83249
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    5. NM_001377086.1NP_001364015.1  NADH-cytochrome b5 reductase-like isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 5, encodes isoform 3.
      Source sequence(s)
      AL607132
      Conserved Domains (2) summary
      cd06183
      Location:83249
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    6. NM_001377087.1NP_001364016.1  NADH-cytochrome b5 reductase-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL607132
      Conserved Domains (2) summary
      cd06183
      Location:83249
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    7. NM_001377088.1NP_001364017.1  NADH-cytochrome b5 reductase-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL607132
      Conserved Domains (2) summary
      cd06183
      Location:83264
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    8. NM_175471.4NP_780680.1  NADH-cytochrome b5 reductase-like isoform 2

      See identical proteins and their annotated locations for NP_780680.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform 2, which has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AL607132
      Consensus CDS
      CCDS38829.1
      UniProtKB/Swiss-Prot
      B1AS42
      Related
      ENSMUSP00000102367.3, ENSMUST00000106756.9
      Conserved Domains (1) summary
      cd06183
      Location:23256
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106924035..106945204
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240482.4XP_011238784.1  NADH-cytochrome b5 reductase-like isoform X7

      Conserved Domains (2) summary
      cd06183
      Location:147355
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    2. XM_030253429.2XP_030109289.1  NADH-cytochrome b5 reductase-like isoform X10

      Conserved Domains (2) summary
      cd06183
      Location:147313
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    3. XM_036164016.1XP_036019909.1  NADH-cytochrome b5 reductase-like isoform X16

      Conserved Domains (2) summary
      cd06183
      Location:147278
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    4. XM_017320133.3XP_017175622.1  NADH-cytochrome b5 reductase-like isoform X20

      Conserved Domains (2) summary
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
      cl06868
      Location:147211
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    5. XM_006502946.5XP_006503009.1  NADH-cytochrome b5 reductase-like isoform X1

      Conserved Domains (2) summary
      cd06183
      Location:147355
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    6. XM_006502947.5XP_006503010.1  NADH-cytochrome b5 reductase-like isoform X2

      Conserved Domains (2) summary
      cd06183
      Location:147422
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    7. XM_006502950.5XP_006503013.1  NADH-cytochrome b5 reductase-like isoform X4

      Conserved Domains (2) summary
      cd06183
      Location:147313
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    8. XM_006502954.5XP_006503017.1  NADH-cytochrome b5 reductase-like isoform X6

      Conserved Domains (2) summary
      cd06183
      Location:147278
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    9. XM_006502955.4XP_006503018.1  NADH-cytochrome b5 reductase-like isoform X8

      Conserved Domains (2) summary
      cd06183
      Location:147345
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    10. XM_006502948.5XP_006503011.1  NADH-cytochrome b5 reductase-like isoform X3

      Conserved Domains (2) summary
      cd06183
      Location:123331
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:5392
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    11. XM_036164013.1XP_036019906.1  NADH-cytochrome b5 reductase-like isoform X9

      Conserved Domains (2) summary
      cd06183
      Location:123254
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:5392
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    12. XM_036164014.1XP_036019907.1  NADH-cytochrome b5 reductase-like isoform X12

      Conserved Domains (2) summary
      cd06183
      Location:123321
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:5392
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    13. XM_036164018.1XP_036019911.1  NADH-cytochrome b5 reductase-like isoform X18

      Conserved Domains (2) summary
      cd06183
      Location:147244
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    14. XM_036164019.1XP_036019912.1  NADH-cytochrome b5 reductase-like isoform X19

      Conserved Domains (2) summary
      cd06183
      Location:123220
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:5392
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    15. XM_006502957.5XP_006503020.1  NADH-cytochrome b5 reductase-like isoform X11

      Conserved Domains (2) summary
      pfam09791
      Location:77116
      Oxidored-like; Oxidoreductase-like protein, N-terminal
      cl06868
      Location:147210
      FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
    16. XM_006502952.5XP_006503015.1  NADH-cytochrome b5 reductase-like isoform X5

      See identical proteins and their annotated locations for XP_006503015.1

      Conserved Domains (2) summary
      cd06183
      Location:83291
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    17. XM_036164015.1XP_036019908.1  NADH-cytochrome b5 reductase-like isoform X14

      UniProtKB/Swiss-Prot
      B1AS41, B1AS42, Q571N5, Q80W48, Q99KB7
      Conserved Domains (2) summary
      cd06183
      Location:83316
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    18. XM_036164020.1XP_036019913.1  NADH-cytochrome b5 reductase-like isoform X21

      Conserved Domains (1) summary
      cd06183
      Location:23189
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    19. XM_006502959.4XP_006503022.1  NADH-cytochrome b5 reductase-like isoform X13

      See identical proteins and their annotated locations for XP_006503022.1

      Conserved Domains (1) summary
      cd06183
      Location:23231
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    20. XM_006502951.4XP_006503014.1  NADH-cytochrome b5 reductase-like isoform X5

      See identical proteins and their annotated locations for XP_006503014.1

      Conserved Domains (2) summary
      cd06183
      Location:83291
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    21. XM_036164017.1XP_036019910.1  NADH-cytochrome b5 reductase-like isoform X17

      Related
      ENSMUSP00000030364.7, ENSMUST00000030364.13
      Conserved Domains (2) summary
      cd06183
      Location:83281
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
      pfam09791
      Location:1352
      Oxidored-like; Oxidoreductase-like protein, N-terminal
    22. XM_006502962.5XP_006503025.1  NADH-cytochrome b5 reductase-like isoform X15

      See identical proteins and their annotated locations for XP_006503025.1

      Conserved Domains (1) summary
      cd06183
      Location:2206
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    23. XM_011240484.4XP_011238786.1  NADH-cytochrome b5 reductase-like isoform X15

      See identical proteins and their annotated locations for XP_011238786.1

      Conserved Domains (1) summary
      cd06183
      Location:2206
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...

    RNA

    1. XR_004941866.1 RNA Sequence

    2. XR_376304.5 RNA Sequence

    3. XR_004941865.1 RNA Sequence

    4. XR_004941867.1 RNA Sequence

    5. XR_003954908.2 RNA Sequence