Synpo2 synaptopodin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Synpo2provided by MGI
Official Full Name: synaptopodin 2provided by MGI
Primary source: MGI:MGI:2153070
See related: Ensembl:ENSMUSG00000050315 AllianceGenome:MGI:2153070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Myo; 1110069I04Rik; 2310068J10Rik; 9530006G20Rik
Summary: Enables 14-3-3 protein binding activity and muscle alpha-actinin binding activity. Predicted to be involved in several processes, including chaperone-mediated autophagy; positive regulation of actin filament bundle assembly; and regulation of Rho-dependent protein serine/threonine kinase activity. Located in nucleus. Is expressed in genitourinary system. Orthologous to human SYNPO2 (synaptopodin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in bladder adult (RPKM 58.2), subcutaneous fat pad adult (RPKM 12.4) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 G1; 3 53.8 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (122870168..123029817, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (123076519..123236168, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
Title: Isoform-specific functions of synaptopodin-2 variants in cytoskeleton stabilization and autophagy regulation in muscle under mechanical stress.
The identification of myopodin as a direct target of PKA, CaMKII, and calcineurin defines a novel intracellular signaling pathway whereby changes in Z-disc dynamics may translate into compartmentalized signal transduction in the heart.
Title: Protein kinase A, Ca2+/calmodulin-dependent kinase II, and calcineurin regulate the intracellular trafficking of myopodin between the Z-disc and the nucleus of cardiac myocytes.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BI292098 (e-PCR)
- UniSTS:245146

AI848603 (e-PCR)
- UniSTS:178922

MARC_23807-23808:1027629864:1 (e-PCR)
- UniSTS:268780

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	ISA Inferred from Sequence Alignment more info	PubMed
enables alpha-actinin binding	ISO Inferred from Sequence Orthology more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables muscle alpha-actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in autophagosome assembly	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	ISA Inferred from Sequence Alignment more info	PubMed
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISS Inferred from Sequence or Structural Similarity more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info
part_of vesicle tethering complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptopodin-2

Names: myopodin; mypodin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001388502.1 → NP_001375431.1 synaptopodin-2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121315, AC121540

UniProtKB/Swiss-Prot

Q8C592, Q91YE8

UniProtKB/TrEMBL

B2RY03

Related

ENSMUSP00000142508.2, ENSMUST00000198584.2

Conserved Domains (2) summary

PHA03247
Location:571 → 1073

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:7 → 85

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
NM_001389265.1 → NP_001376194.1 synaptopodin-2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121540

Conserved Domains (1) summary

PHA03247
Location:186 → 688

PHA03247; large tegument protein UL36; Provisional
NM_001389266.1 → NP_001376195.1 synaptopodin-2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121540

UniProtKB/TrEMBL

A0A498WGE8

Related

ENSMUSP00000051570.8, ENSMUST00000051443.8

Conserved Domains (1) summary

PHA03247
Location:186 → 688

PHA03247; large tegument protein UL36; Provisional
NM_080451.2 → NP_536699.2 synaptopodin-2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121315, AC121540

Consensus CDS

CCDS51063.1

UniProtKB/TrEMBL

B2RY03, E9Q1U2

Related

ENSMUSP00000102034.2, ENSMUST00000106426.8

Conserved Domains (1) summary

cd00992
Location:7 → 85

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

122870168..123029817 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500925.4 → XP_006500988.1 synaptopodin-2 isoform X1

UniProtKB/TrEMBL

B2RY03

Conserved Domains (2) summary

PHA03247
Location:571 → 1073

PHA03247; large tegument protein UL36; Provisional

cd00992
Location:7 → 85

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...