U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Neurog2 neurogenin 2 [ Mus musculus (house mouse) ]

    Gene ID: 11924, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neurog2provided by MGI
    Official Full Name
    neurogenin 2provided by MGI
    Primary source
    MGI:MGI:109619
    See related
    Ensembl:ENSMUSG00000027967 AllianceGenome:MGI:109619
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ngn2; Atoh4; ngn-2; Math4A; bHLHa8
    Summary
    Enables E-box binding activity. Involved in positive regulation of DNA-binding transcription factor activity. Acts upstream of or within several processes, including generation of neurons; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; eye; and integumental system. Orthologous to human NEUROG2 (neurogenin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E14 (RPKM 28.5), whole brain E14.5 (RPKM 22.8) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Neurog2 in Genome Data Viewer
    Location:
    3 G2; 3 56.54 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (127426382..127429285)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (127632733..127635636)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:127256185-127256372 Neighboring gene zinc finger, GRF-type containing 1 Neighboring gene STARR-seq mESC enhancer starr_08956 Neighboring gene predicted gene, 40147 Neighboring gene alpha-kinase 1 Neighboring gene STARR-seq mESC enhancer starr_08957 Neighboring gene VISTA enhancer mm1549 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E335 Neighboring gene STARR-positive B cell enhancer ABC_E6120 Neighboring gene STARR-positive B cell enhancer ABC_E6121 Neighboring gene TRAF-interacting protein with forkhead-associated domain

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (12)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables E-box binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of Cajal-Retzius cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in axon development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in forebrain development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neurogenin-2
    Names
    atonal homolog 4
    helix-loop-helix protein mATH-4A
    protein atonal homolog 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009718.4NP_033848.1  neurogenin-2

      See identical proteins and their annotated locations for NP_033848.1

      Status: VALIDATED

      Source sequence(s)
      AC158308
      Consensus CDS
      CCDS17825.1
      UniProtKB/Swiss-Prot
      P70237, P70447
      UniProtKB/TrEMBL
      I3PQW5, Q6GTH9
      Related
      ENSMUSP00000029587.8, ENSMUST00000029587.9
      Conserved Domains (1) summary
      cd19717
      Location:104172
      bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      127426382..127429285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252394.1XP_030108254.1  neurogenin-2 isoform X1

      UniProtKB/Swiss-Prot
      P70237, P70447
      UniProtKB/TrEMBL
      I3PQW5, Q6GTH9
      Conserved Domains (1) summary
      cd19717
      Location:104172
      bHLH_TS_NGN2_ATOH4; basic helix-loop-helix (bHLH) domain found in neurogenin-2 (NGN-2) and similar proteins