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    Ltb lymphotoxin B [ Mus musculus (house mouse) ]

    Gene ID: 16994, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ltbprovided by MGI
    Official Full Name
    lymphotoxin Bprovided by MGI
    Primary source
    MGI:MGI:104796
    See related
    Ensembl:ENSMUSG00000024399 AllianceGenome:MGI:104796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p33; Tnfc; LTbeta; Tnfsf3; Tnlg1c
    Summary
    Predicted to enable cytokine activity. Involved in positive regulation of interleukin-12 production. Acts upstream of or within gene expression; lymph node development; and skin development. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including brain; hemolymphoid system; liver; lung; and reproductive system. Orthologous to human LTB (lymphotoxin beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 307.1), thymus adult (RPKM 119.5) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    See Ltb in Genome Data Viewer
    Location:
    17 B1; 17 18.59 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35413483..35415281)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (35194507..35196305)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene natural cytotoxicity triggering receptor 3, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E11796 Neighboring gene leukocyte specific transcript 1 Neighboring gene microRNA 6973a Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:35337508-35337695 Neighboring gene tumor necrosis factor Neighboring gene microRNA 6974 Neighboring gene lymphotoxin A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (8)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    lymphotoxin-beta
    Names
    LT-beta
    TNF-C
    tumor necrosis factor C
    tumor necrosis factor ligand 1c
    tumor necrosis factor ligand superfamily member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008518.2NP_032544.1  lymphotoxin-beta

      See identical proteins and their annotated locations for NP_032544.1

      Status: VALIDATED

      Source sequence(s)
      BC064062, CR974444, U16985
      Consensus CDS
      CCDS28690.1
      UniProtKB/Swiss-Prot
      P41155
      UniProtKB/TrEMBL
      A0A0U5JAA2, A4FUI4
      Related
      ENSMUSP00000025262.6, ENSMUST00000025262.6
      Conserved Domains (1) summary
      cd00184
      Location:154303
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35413483..35415281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)