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    Neurl2 neuralized E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

    Gene ID: 415115, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neurl2provided by MGI
    Official Full Name
    neuralized E3 ubiquitin protein ligase 2provided by MGI
    Primary source
    MGI:MGI:3043305
    See related
    Ensembl:ENSMUSG00000039873 AllianceGenome:MGI:3043305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ozz; Neur2; Ozz-E3
    Summary
    Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within sarcomere organization. Located in muscle tendon junction. Part of VCB complex. Is expressed in forebrain; gonad; metanephros; and submandibular gland. Orthologous to human NEURL2 (neuralized E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 18.2), ovary adult (RPKM 15.2) and 27 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Neurl2 in Genome Data Viewer
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (164672650..164675516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (164830730..164833596, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06336 Neighboring gene zinc finger SWIM-type containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6018 Neighboring gene spermatogenesis associated 25 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:164659262-164659371 Neighboring gene cathepsin A Neighboring gene phospholipid transfer protein Neighboring gene STARR-seq mESC enhancer starr_06339 Neighboring gene RIKEN cDNA 4930445K14 gene Neighboring gene STARR-positive B cell enhancer ABC_E6019 Neighboring gene STARR-positive B cell enhancer ABC_E2059 Neighboring gene phosphorylated CTD interacting factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of VCB complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuralized-like protein 2
    Names
    neuralized-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082974.2NP_001076443.1  neuralized-like protein 2

      See identical proteins and their annotated locations for NP_001076443.1

      Status: VALIDATED

      Source sequence(s)
      AL591495
      Consensus CDS
      CCDS38330.1
      UniProtKB/Swiss-Prot
      Q9D0S4
      UniProtKB/TrEMBL
      A2A5J5
      Related
      ENSMUSP00000041806.5, ENSMUST00000042775.5
      Conserved Domains (2) summary
      smart00969
      Location:249285
      SOCS_box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases
      cd12887
      Location:25242
      SPRY_NHR_like; SPRY domain in neuralized homology repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      164672650..164675516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)