Cptp ceramide-1-phosphate transfer protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cptpprovided by MGI
Official Full Name: ceramide-1-phosphate transfer proteinprovided by MGI
Primary source: MGI:MGI:1933107
See related: Ensembl:ENSMUSG00000029073 AllianceGenome:MGI:1933107
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gltpd1
Summary: Predicted to enable ceramide 1-phosphate binding activity and ceramide 1-phosphate transfer activity. Involved in negative regulation of interleukin-1 beta production. Predicted to be located in Golgi apparatus; bounding membrane of organelle; and plasma membrane. Predicted to be active in cytosol. Orthologous to human CPTP (ceramide-1-phosphate transfer protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 70.7), large intestine adult (RPKM 15.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 87.66 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155949180..155953897, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155864723..155869440, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

crystal structure of CPTP
Title: Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D4Mon3 (e-PCR)
- UniSTS:240993

NoName (e-PCR)
- UniSTS:235122

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ceramide 1-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide 1-phosphate binding	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables ceramide 1-phosphate transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables ceramide 1-phosphate transfer activity	ISO Inferred from Sequence Orthology more info
enables ceramide 1-phosphate transfer activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide 1-phosphate transport	ISO Inferred from Sequence Orthology more info
involved_in ceramide 1-phosphate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in ceramide transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermembrane lipid transfer	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ceramide-1-phosphate transfer protein

Names: glycolipid transfer protein domain containing 1; glycolipid transfer protein domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.