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    Tspan10 tetraspanin 10 [ Mus musculus (house mouse) ]

    Gene ID: 208634, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tspan10provided by MGI
    Official Full Name
    tetraspanin 10provided by MGI
    Primary source
    MGI:MGI:2384781
    See related
    Ensembl:ENSMUSG00000039691 AllianceGenome:MGI:2384781
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ocsp
    Summary
    Enables enzyme binding activity. Involved in protein maturation. Predicted to be active in plasma membrane. Orthologous to human TSPAN10 (tetraspanin 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 3.1) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspan10 in Genome Data Viewer
    Location:
    11 E2; 11 84.13 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120333457..120338147)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120442631..120447321)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Fanconi anemia core complex associated protein 100 Neighboring gene NPL4 homolog, ubiquitin recognition factor Neighboring gene STARR-seq mESC enhancer starr_31358 Neighboring gene STARR-seq mESC enhancer starr_31359 Neighboring gene phosphodiesterase 6G, cGMP-specific, rod, gamma Neighboring gene oxidoreductase like domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of Notch modulators, tetraspanin 5 and 10, inhibits osteoclastogenesis in vitro. Zhou J, et al. Calcif Tissue Int, 2014 Sep. PMID 24935633, Free PMC Article
    2. The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression. Haining EJ, et al. J Biol Chem, 2012 Nov 16. PMID 23035126, Free PMC Article
    3. Appearance of new tetraspanin genes during vertebrate evolution. Garcia-España A, et al. Genomics, 2008 Apr. PMID 18291621
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-10
    Names
    oculospanin
    tspan-10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145363.2 → NP_663338.2  tetraspanin-10

      See identical proteins and their annotated locations for NP_663338.2

      Status: VALIDATED

      Source sequence(s)
      AK148326, BY479111, CK625019
      Consensus CDS
      CCDS25733.2
      UniProtKB/Swiss-Prot
      Q8VCF5
      UniProtKB/TrEMBL
      Q3UFS7, Q3UGA5
      Related
      ENSMUSP00000041883.9, ENSMUST00000044105.9
      Conserved Domains (2) summary
      cd03167
      Location:171 → 290
      oculospanin_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:74 → 304
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      120333457..120338147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCF5.1 GenPept UniProtKB/Swiss-Prot:Q8VCF5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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