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    Snx10 sorting nexin 10 [ Mus musculus (house mouse) ]

    Gene ID: 71982, updated on 9-Dec-2024

    Summary

    Official Symbol
    Snx10provided by MGI
    Official Full Name
    sorting nexin 10provided by MGI
    Primary source
    MGI:MGI:1919232
    See related
    Ensembl:ENSMUSG00000038301 AllianceGenome:MGI:1919232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410004M09Rik
    Summary
    Predicted to enable 1-phosphatidylinositol binding activity; ATPase binding activity; and phosphatidylinositol phosphate binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including bone mineralization involved in bone maturation; bone resorption; and cellular response to leukemia inhibitory factor. Located in several cellular components, including apical cytoplasm; endoplasmic reticulum; and secretory granule. Is expressed in chondrocranium; incisor; limb; and nose. Used to study autosomal recessive osteopetrosis 8. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 8. Orthologous to human SNX10 (sorting nexin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 11.5), cortex adult (RPKM 10.9) and 17 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Snx10 in Genome Data Viewer
    Location:
    6 B3; 6 24.95 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (51500882..51567659)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (51523900..51590679)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15871 Neighboring gene STARR-seq mESC enhancer starr_15873 Neighboring gene nuclear factor, erythroid derived 2, like 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A2/B1 Neighboring gene STARR-seq mESC enhancer starr_15875 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:51459345-51459528 Neighboring gene STARR-seq mESC enhancer starr_15881 Neighboring gene chromobox 3 Neighboring gene predicted gene, 52883 Neighboring gene predicted gene, 53331 Neighboring gene STARR-seq mESC enhancer starr_15887 Neighboring gene STARR-seq mESC enhancer starr_15888 Neighboring gene STARR-positive B cell enhancer mm9_chr6:51663532-51663833 Neighboring gene predicted gene, 38811 Neighboring gene STARR-seq mESC enhancer starr_15891 Neighboring gene VISTA enhancer mm412 Neighboring gene src family associated phosphoprotein 2 Neighboring gene STARR-seq mESC enhancer starr_15896 Neighboring gene STARR-seq mESC enhancer starr_15897

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 1-phosphatidylinositol binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone mineralization involved in bone maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within bone resorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastric acid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within tooth eruption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vesicle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extrinsic component of endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127348.1NP_001120820.1  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_001120820.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK028163, AK150878, AK151320, AK166121
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000136974.2, ENSMUST00000179365.8
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    2. NM_001127349.1NP_001120821.1  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_001120821.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK150878, AK151320
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000044165.9, ENSMUST00000049152.15
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    3. NM_001361576.1NP_001348505.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longer isoform (a). Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000117914.2, ENSMUST00000137212.8
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    4. NM_001361577.1NP_001348506.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    5. NM_001361578.1NP_001348507.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    6. NM_001361579.1NP_001348508.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    7. NM_001361580.1NP_001348509.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    8. NM_001361581.1NP_001348510.1  sorting nexin-10 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AC153877
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    9. NM_001361582.1NP_001348511.1  sorting nexin-10 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and coding sequence compared to variant 4. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC153877
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    10. NM_028035.4NP_082311.3  sorting nexin-10 isoform a

      See identical proteins and their annotated locations for NP_082311.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 4. Variants 1-9 all encode the same isoform (a).
      Source sequence(s)
      AK028163, AK150878, AK151320
      Consensus CDS
      CCDS20136.1
      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Related
      ENSMUSP00000110082.2, ENSMUST00000114439.8
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      51500882..51567659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255600.2XP_030111460.1  sorting nexin-10 isoform X1

      UniProtKB/Swiss-Prot
      Q8C1E0, Q9CWT3
      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7, Q4FJX6
      Conserved Domains (1) summary
      cd06898
      Location:12109
      PX_SNX10; The phosphoinositide binding Phox Homology domain of Sorting Nexin 10
    2. XM_036152314.1XP_036008207.1  sorting nexin-10 isoform X2

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    3. XM_036152316.1XP_036008209.1  sorting nexin-10 isoform X2

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
    4. XM_011241474.1XP_011239776.1  sorting nexin-10 isoform X2

      See identical proteins and their annotated locations for XP_011239776.1

      UniProtKB/TrEMBL
      Q3U6V6, Q3U746, Q3UBN7
      Conserved Domains (1) summary
      cl02563
      Location:169
      PX_domain; The Phox Homology domain, a phosphoinositide binding module