Bcan brevican [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bcanprovided by MGI
Official Full Name: brevicanprovided by MGI
Primary source: MGI:MGI:1096385
See related: Ensembl:ENSMUSG00000004892 AllianceGenome:MGI:1096385
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cspg7
Summary: Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in synapse maturation. Acts upstream of or within hippocampus development. Located in perineuronal net. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; lower jaw; sensory organ; and spinal cord. Human ortholog(s) of this gene implicated in high grade glioma. Orthologous to human BCAN (brevican). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in frontal lobe adult (RPKM 53.5), cortex adult (RPKM 50.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.78 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87894839..87908458, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87987531..88002175, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Title: Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses.
Brevican expression in the auditory cortex is upregulated during consolidation of long-term memories.
Title: Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories.
Genetic deletion of brevican, one of the main components, resulted in a massive degradation of extracellular matrix baskets at inner hair cells, a significant impairment in spatial coupling of pre- and postsynaptic elements and mild impairment of hearing.
Title: Synaptic coupling of inner ear sensory cells is controlled by brevican-based extracellular matrix baskets resembling perineuronal nets.
intrachromosomal deletion generating a fusion between BCAN and NTRK1 drives the formation of aggressive high-grade gliomas and confers sensitivity to entrectinib
Title: Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target.
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack brevican, the informational content stored by synaptic plasticity is not the same.
Title: Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules.
This study found that mice with reduced brevican levels show enhanced locomotor activity to acute cocaine and a progressive increase in expression of cocaine CPP during forced abstinence.
Title: The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference.
The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held
Title: The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held.
This study provided evidence that the brevican modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Title: Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation.
these results imply that Bral2-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets
Title: Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum.
defective brevican processing observed in amyloid beta-bearing mice may contribute to deficient neural plasticity
Title: Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Bcan (e-PCR), detects polymorphism
- UniSTS:141158

Bcan (e-PCR), detects polymorphism
- UniSTS:506749

UniSTS:224394 (e-PCR)
- UniSTS:224394

X87096 (e-PCR)
- UniSTS:159134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables hyaluronic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection extension	ISO Inferred from Sequence Orthology more info
involved_in skeletal system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse maturation	IEP Inferred from Expression Pattern more info	PubMed
involved_in synapse maturation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in node of Ranvier	ISO Inferred from Sequence Orthology more info
is_active_in perineuronal net	IBA Inferred from Biological aspect of Ancestor more info
located_in perineuronal net	IDA Inferred from Direct Assay more info	PubMed
located_in perineuronal net	ISO Inferred from Sequence Orthology more info
is_active_in perisynaptic extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: brevican core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109758.2 → NP_001103228.1 brevican core protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/Swiss-Prot

Q61361

UniProtKB/TrEMBL

Q3TSQ8

Related

ENSMUST00000192274.6

Conserved Domains (4) summary

smart00410
Location:43 → 153

IG_like; Immunoglobulin like

cd03517
Location:156 → 250

Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...

cd03520
Location:257 → 352

Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...

cl11960
Location:48 → 157

Ig; Immunoglobulin domain
NM_001409541.1 → NP_001396470.1 brevican core protein isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/Swiss-Prot

Q61361, Q80WT7
NM_001409542.1 → NP_001396471.1 brevican core protein isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/Swiss-Prot

Q61361, Q80WT7
NM_001409543.1 → NP_001396472.1 brevican core protein isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/Swiss-Prot

Q61361, Q80WT7
NM_001409545.1 → NP_001396474.1 brevican core protein isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC158233

UniProtKB/Swiss-Prot

Q61361, Q80WT7
NM_001409546.1 → NP_001396475.1 brevican core protein isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409547.1 → NP_001396476.1 brevican core protein isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409548.1 → NP_001396477.1 brevican core protein isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409549.1 → NP_001396478.1 brevican core protein isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409550.1 → NP_001396479.1 brevican core protein isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409551.1 → NP_001396480.1 brevican core protein isoform 6 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409552.1 → NP_001396481.1 brevican core protein isoform 7

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409553.1 → NP_001396482.1 brevican core protein isoform 8 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409554.1 → NP_001396483.1 brevican core protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409555.1 → NP_001396484.1 brevican core protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409556.1 → NP_001396485.1 brevican core protein isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_001409557.1 → NP_001396486.1 brevican core protein isoform 9 precursor

Status: VALIDATED

Source sequence(s)

AC158233
NM_007529.3 → NP_031555.2 brevican core protein isoform 1 precursor

See identical proteins and their annotated locations for NP_031555.2

Status: VALIDATED

Source sequence(s)

AC158233

Consensus CDS

CCDS17462.1

UniProtKB/Swiss-Prot

Q61361, Q80WT7

Related

ENSMUSP00000088491.6, ENSMUST00000090971.11

Conserved Domains (8) summary

cd00033
Location:791 → 848

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03517
Location:156 → 250

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...

cd03520
Location:257 → 352

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...

pfam00008
Location:626 → 655

EGF; EGF-like domain

pfam03546
Location:482 → 615

Treacle; Treacher Collins syndrome protein Treacle

cd00096
Location:44 → 46

Ig; Ig strand A' [structural motif]

cl02432
Location:664 → 787

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl11960
Location:44 → 158

Ig; Immunoglobulin domain

RNA

NR_176864.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC158233
NR_176865.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC158233

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

87894839..87908458 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162863.1 → XP_036018756.1 brevican core protein isoform X1

UniProtKB/Swiss-Prot

Q61361, Q80WT7

Conserved Domains (8) summary

cd00033
Location:791 → 848

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03517
Location:156 → 250

Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: versican, neurocan, and brevican. ...

cd03520
Location:257 → 352

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...

pfam00008
Location:626 → 655

EGF; EGF-like domain

pfam03546
Location:482 → 615

Treacle; Treacher Collins syndrome protein Treacle

cd00096
Location:44 → 46

Ig; Ig strand A' [structural motif]

cl02432
Location:664 → 787

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl11960
Location:44 → 158

Ig; Immunoglobulin domain
XM_036162865.1 → XP_036018758.1 brevican core protein isoform X3

Conserved Domains (6) summary

cd00033
Location:565 → 622

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd03520
Location:31 → 126

Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The link domain is a hyaluronan ...

pfam00008
Location:400 → 429

EGF; EGF-like domain

pfam03546
Location:256 → 389

Treacle; Treacher Collins syndrome protein Treacle

cl02432
Location:438 → 561

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl02612
Location:1 → 24

Link_Domain; The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor ...