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    Acot11 acyl-CoA thioesterase 11 [ Mus musculus (house mouse) ]

    Gene ID: 329910, updated on 9-Dec-2024

    Summary

    Official Symbol
    Acot11provided by MGI
    Official Full Name
    acyl-CoA thioesterase 11provided by MGI
    Primary source
    MGI:MGI:1913736
    See related
    Ensembl:ENSMUSG00000034853 AllianceGenome:MGI:1913736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BFIT; Thea; BFIT1; Them1; mKIAA0707; 1110020M10Rik; 2010309H15Rik
    Summary
    Predicted to enable long-chain fatty acyl-CoA hydrolase activity. Involved in negative regulation of cold-induced thermogenesis and response to cold. Predicted to be located in mitochondrial matrix. Predicted to be active in cytosol. Orthologous to human ACOT11 (acyl-CoA thioesterase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in small intestine adult (RPKM 28.1), large intestine adult (RPKM 26.5) and 20 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Acot11 in Genome Data Viewer
    Location:
    4 C7; 4 49.75 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106601752..106662204, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (106744555..106805007, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 4 Neighboring gene STARR-positive B cell enhancer ABC_E6195 Neighboring gene maestro heat-like repeat family member 7 Neighboring gene family with sequence simliarity 151, member A Neighboring gene STARR-positive B cell enhancer ABC_E4640 Neighboring gene predicted gene, 31065 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:106500407-106500594 Neighboring gene STARR-seq mESC enhancer starr_11003 Neighboring gene predicted gene, 31125

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25974

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables fatty acyl-CoA hydrolase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables long-chain fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acyl-CoA hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables long-chain fatty acyl-CoA hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in fatty acid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to cold IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to temperature stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    acyl-coenzyme A thioesterase 11
    Names
    acyl-CoA thioester hydrolase 11
    adipose-associated thioesterase
    brown fat-inducible thioesterase
    palmitoyl-coenzyme A thioesterase
    thioesterase, adipose associated
    NP_001334088.1
    NP_079866.2
    XP_011238858.1
    XP_036020090.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347159.1NP_001334088.1  acyl-coenzyme A thioesterase 11 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AL929585
      Consensus CDS
      CCDS84764.1
      UniProtKB/TrEMBL
      A2AVR6, Q80TT9
      Related
      ENSMUSP00000069636.7, ENSMUST00000065253.13
    2. NM_025590.4NP_079866.2  acyl-coenzyme A thioesterase 11 isoform 2

      See identical proteins and their annotated locations for NP_079866.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to variant 1.
      Source sequence(s)
      AK048670, AL929585
      Consensus CDS
      CCDS18426.1
      UniProtKB/Swiss-Prot
      Q8VHQ9
      UniProtKB/TrEMBL
      Q543P6, Q80TT9
      Related
      ENSMUSP00000099823.4, ENSMUST00000102762.10
      Conserved Domains (2) summary
      cd03442
      Location:214337
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      cl14643
      Location:345583
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      106601752..106662204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240556.2XP_011238858.1  acyl-coenzyme A thioesterase 11 isoform X1

      See identical proteins and their annotated locations for XP_011238858.1

      UniProtKB/TrEMBL
      Q80TT9, Q8CAL6
      Conserved Domains (2) summary
      cd03442
      Location:199322
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      cl14643
      Location:330568
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    2. XM_036164197.1XP_036020090.1  acyl-coenzyme A thioesterase 11 isoform X2

      UniProtKB/TrEMBL
      Q80TT9
      Conserved Domains (3) summary
      cd03442
      Location:90213
      BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
      cl00509
      Location:166
      hot_dog; The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated ...
      cl14643
      Location:221459
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily