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    Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) [ Mus musculus (house mouse) ]

    Gene ID: 20391, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sgcaprovided by MGI
    Official Full Name
    sarcoglycan, alpha (dystrophin-associated glycoprotein)provided by MGI
    Primary source
    MGI:MGI:894698
    See related
    Ensembl:ENSMUSG00000001508 AllianceGenome:MGI:894698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Asg; 50DAG
    Summary
    This gene encodes a member of the sarcoglycan alpha/epsilon family of transmembrane proteins. The encoded protein is part of the dystrophin-glycoprotein complex which links the extracellular matrix to the cytoskeleton in muscle fibers. Disruption of this gene results in progressive muscular dystrophy and is associated with the development of embryonal rhabdomysarcoma. [provided by RefSeq, Dec 2012]
    Expression
    Biased expression in heart adult (RPKM 125.0), mammary gland adult (RPKM 27.0) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Sgca in Genome Data Viewer
    Location:
    11 D; 11 59.01 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94853603..94867153, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94962777..94976327, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46293 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94798366-94798667 Neighboring gene collagen, type I, alpha 1 Neighboring gene STARR-seq mESC enhancer starr_30476 Neighboring gene H1.9 linker histone Neighboring gene STARR-positive B cell enhancer ABC_E7047 Neighboring gene STARR-seq mESC enhancer starr_30478 Neighboring gene STARR-seq mESC enhancer starr_30479 Neighboring gene STARR-positive B cell enhancer ABC_E3995 Neighboring gene protein phosphatase 1, regulatory subunit 9B Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94859496-94859731 Neighboring gene predicted gene, 51875 Neighboring gene sterile alpha motif domain containing 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (6)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystroglycan complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of sarcoglycan complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sarcoglycan complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-sarcoglycan
    Names
    50 kDa dystrophin-associated glycoprotein
    adhalin
    alpha-SG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009161.4NP_033187.1  alpha-sarcoglycan precursor

      See identical proteins and their annotated locations for NP_033187.1

      Status: REVIEWED

      Source sequence(s)
      AK075915, AL606480
      Consensus CDS
      CCDS25266.1
      UniProtKB/Swiss-Prot
      O35311, O88490, P82350
      Related
      ENSMUSP00000099451.2, ENSMUST00000103162.8
      Conserved Domains (1) summary
      pfam05510
      Location:27347
      Sarcoglycan_2; Sarcoglycan alpha/epsilon

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94853603..94867153 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248836.4XP_011247138.1  alpha-sarcoglycan isoform X1

      See identical proteins and their annotated locations for XP_011247138.1

      UniProtKB/Swiss-Prot
      O35311, O88490, P82350
      Conserved Domains (1) summary
      pfam05510
      Location:27347
      Sarcoglycan_2; Sarcoglycan alpha/epsilon