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    Cflar CASP8 and FADD-like apoptosis regulator [ Mus musculus (house mouse) ]

    Gene ID: 12633, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cflarprovided by MGI
    Official Full Name
    CASP8 and FADD-like apoptosis regulatorprovided by MGI
    Primary source
    MGI:MGI:1336166
    See related
    Ensembl:ENSMUSG00000026031 AllianceGenome:MGI:1336166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cash; Flip; MRIT; CLARP; FLAME; Casper; Gm9845; c-Flip; FLAME-1; I-FLICE; 2310024N18Rik; A430105C05Rik
    Summary
    Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; positive regulation of NF-kappaB transcription factor activity; and skeletal muscle atrophy. Acts upstream of or within negative regulation of programmed cell death and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 9.2), kidney adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cflar in Genome Data Viewer
    Location:
    1 C1.3; 1 29.16 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58750353..58798043)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58711311..58758884)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01018 Neighboring gene caspase 8 pseudogene Neighboring gene flagellum associated containing coiled-coil domains 1 Neighboring gene STARR-seq mESC enhancer starr_01019 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58750575-58750876 Neighboring gene STARR-positive B cell enhancer ABC_E790 Neighboring gene STARR-positive B cell enhancer ABC_E5758 Neighboring gene STARR-seq mESC enhancer starr_01021 Neighboring gene STARR-seq mESC enhancer starr_01022 Neighboring gene STARR-positive B cell enhancer ABC_E1220 Neighboring gene STARR-seq mESC enhancer starr_01023 Neighboring gene predicted gene, 39646 Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene caspase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC103395

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables death receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptidase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of epithelial cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of necroptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glomerular mesangial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of hepatocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in skeletal muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in skeletal myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CD95 death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of death-inducing signaling complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ripoptosome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    FADD-like antiapoptotic molecule 1
    MACH-related inducer of toxicity
    caspase homolog
    caspase-eight-related protein
    caspase-like apoptosis regulatory protein
    cellular FLICE-like inhibitory protein
    inhibitor of FLICE
    usurpin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289704.3NP_001276633.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001276633.1

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Consensus CDS
      CCDS14978.1
      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Related
      ENSMUSP00000109952.2, ENSMUST00000114313.8
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. NM_001293804.2NP_001280733.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001280733.1

      Status: VALIDATED

      Source sequence(s)
      AC112968, AK152515
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    3. NM_001293805.2NP_001280734.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001280734.1

      Status: VALIDATED

      Source sequence(s)
      AC112968, AK161120
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    4. NM_001355056.1NP_001341985.1  CASP8 and FADD-like apoptosis regulator isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    5. NM_009805.4NP_033935.2  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_033935.2

      Status: VALIDATED

      Source sequence(s)
      BB856464, BC085105
      Consensus CDS
      CCDS35582.1
      UniProtKB/TrEMBL
      Q5U4G3
      Related
      ENSMUSP00000109948.2, ENSMUST00000114309.8
      Conserved Domains (2) summary
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. NM_207653.6NP_997536.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_997536.1

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Consensus CDS
      CCDS14978.1
      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Related
      ENSMUSP00000065107.8, ENSMUST00000069333.8
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RNA

    1. NR_149255.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968
    2. NR_149256.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Related
      ENSMUST00000156870.2
    3. NR_149257.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968, BX524743
      Related
      ENSMUST00000124567.2
    4. NR_149258.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC112968
      Related
      ENSMUST00000149874.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58750353..58798043
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238421.4XP_011236723.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236723.1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Related
      ENSMUSP00000095329.3, ENSMUST00000097722.9
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. XM_011238420.4XP_011236722.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236722.1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    3. XM_030244988.2XP_030100848.1  CASP8 and FADD-like apoptosis regulator isoform X1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    4. XM_011238422.1XP_011236724.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236724.1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    5. XM_011238423.4XP_011236725.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_011236725.1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. XM_006495635.5XP_006495698.1  CASP8 and FADD-like apoptosis regulator isoform X1

      See identical proteins and their annotated locations for XP_006495698.1

      UniProtKB/Swiss-Prot
      D3Z0W6, O35707, O35732, O35733
      UniProtKB/TrEMBL
      A0A2C9F2D9, Q812G4
      Conserved Domains (3) summary
      smart00115
      Location:246480
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:685
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:96176
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    7. XM_036156889.1XP_036012782.1  CASP8 and FADD-like apoptosis regulator isoform X2

      Conserved Domains (1) summary
      smart00115
      Location:60294
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues