Rybp RING1 and YY1 binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rybpprovided by MGI
Official Full Name: RING1 and YY1 binding proteinprovided by MGI
Primary source: MGI:MGI:1929059
See related: Ensembl:ENSMUSG00000072872 AllianceGenome:MGI:1929059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DEDAF; YEAF1; 2410018J24Rik
Summary: Enables DNA binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. Is expressed in several structures, including central nervous system; early embryo; extraembryonic component; genitourinary system; and hemolymphoid system gland. Orthologous to human RYBP (RING1 and YY1 binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 21.3), CNS E18 (RPKM 18.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 D3; 6 46.62 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (100205526..100264319, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (100228565..100287358, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
Title: Functional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
Title: USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.
Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
Title: Polycomb protein RYBP activates transcription factor Plagl1 during in vitro cardiac differentiation of mouse embryonic stem cells.
RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.
Title: RYBP regulates Pax6 during in vitro neural differentiation of mouse embryonic stem cells.
RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern.
Title: RYBP modulates embryonic neurogenesis involving the Notch signaling pathway in a PRC1-independent pattern.
Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice.
Title: Rybp orchestrates spermatogenesis via regulating meiosis and sperm motility in mice.
Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.
Title: Ring 1 and YY1 Binding Protein Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis.
RYBP is important for cardiac progenitor cell development and sarcomere formation.
Title: RYBP is important for cardiac progenitor cell development and sarcomere formation.
The results suggest that histone H1-dependent chromatin compaction plays a critical role in the stable propagation of H2AK119ub1 by RYBP/YAF2-PRC1 during cell division.
Title: RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division.
Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes.
Title: SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G19717 (e-PCR)
- UniSTS:60274

A001W26 (e-PCR)
- UniSTS:60275

12.MMHAP29FRD9.seq (e-PCR)
- UniSTS:123111

NoName (e-PCR)
- UniSTS:488703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of PcG protein complex	IEA Inferred from Electronic Annotation more info
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RING1 and YY1-binding protein

Names: DED-associated factor; Ring1 interactor Rybp; death effector domain-associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019743.3 → NP_062717.2 RING1 and YY1-binding protein

See identical proteins and their annotated locations for NP_062717.2

Status: PROVISIONAL

Source sequence(s)

AC158655

Consensus CDS

CCDS39579.1

UniProtKB/Swiss-Prot

B2RRB6, Q8CCI5, Q9WVK2

Related

ENSMUSP00000098677.3, ENSMUST00000101118.4

Conserved Domains (3) summary

sd00029
Location:25 → 44

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam00641
Location:22 → 45

zf-RanBP; Zn-finger in Ran binding protein and others

pfam17219
Location:145 → 176

YAF2_RYBP; Yaf2/RYBP C-terminal binding motif